Cell Senescence Entries for BLK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

BLK Gene Information

HGNC symbol
BLK 
Aliases
MGC10442 
Common name
BLK proto-oncogene, Src family tyrosine kinase 
Entrez Id
640
Description
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010].

BLK Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:45087; innate immune response
GO:30154; cell differentiation
GO:6974; cellular response to DNA damage stimulus
GO:31175; neuron projection development
GO:50853; B cell receptor signaling pathway
GO:32092; positive regulation of protein binding
GO:35556; intracellular signal transduction
GO:30889; negative regulation of B cell proliferation
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
And 13 more GO terms
Cellular component: GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:5737; cytoplasm
Function: GO:5524; ATP binding
GO:5515; protein binding
GO:4672; protein kinase activity
GO:4713; protein tyrosine kinase activity
GO:166; nucleotide binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:4715; non-membrane spanning protein tyrosine kinase activity
GO:5102; signaling receptor binding
Show all GO terms

Homologs of BLK in Model Organisms

Caenorhabditis elegans
src-1
Danio rerio
blk
Mus musculus
Blk
Rattus norvegicus
Blk

External links

OMIM
191305
Ensembl
ENSG00000136573
Entrez Gene
640
UniGene
146591
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BLK
GeneCards
BLK