Cell Senescence Entries for BMP4

Cell Types
Lung cancer
Cell Lines
A549, NCI-H1299
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Su et al. (2009) BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. J Biol Chem 284(18)12153-64 (PubMed)

BMP4 Gene Information

HGNC symbol
BMP4 
Aliases
BMP2B 
Common name
bone morphogenetic protein 4 
Entrez Id
652
Description
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. [provided by RefSeq, Jul 2016].

BMP4 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:1822; kidney development
GO:51216; cartilage development
GO:1503; ossification
GO:122; negative regulation of transcription by RNA polymerase II
GO:8284; positive regulation of cell population proliferation
And 185 more GO terms
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5788; endoplasmic reticulum lumen
Function: GO:5515; protein binding
GO:8083; growth factor activity
GO:5125; cytokine activity
GO:42056; chemoattractant activity
GO:39706; co-receptor binding
GO:70700; BMP receptor binding
GO:8201; heparin binding
Show all GO terms

Homologs of BMP4 in Model Organisms

Danio rerio
bmp4
Drosophila melanogaster
dpp
Mus musculus
Bmp4
Rattus norvegicus
Bmp4

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as dpp

External links

OMIM
112262
Ensembl
ENSG00000125378
Entrez Gene
652
UniGene
68879
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BMP4
GeneCards
BMP4