Cell Senescence Entries for BMPR2

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Mutation
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Cassar et al. (2017) TGF-beta receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence. Protein Cell 8(1)39-54 (PubMed)

BMPR2 Gene Information

HGNC symbol
BMPR2 
Aliases
BMPR-II; BMPR3; BRK-3; PPH1; T-ALK 
Common name
bone morphogenetic protein receptor type 2 
Entrez Id
659
Description
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020].

BMPR2 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:50790; regulation of catalytic activity
GO:71902; positive regulation of protein serine/threonine kinase activity
GO:7178; transmembrane receptor protein serine/threonine kinase signaling pathway
GO:30308; negative regulation of cell growth
GO:30509; BMP signaling pathway
GO:30513; positive regulation of BMP signaling pathway
GO:32924; activin receptor signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:2063; chondrocyte development
And 51 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5615; extracellular space
GO:5912; adherens junction
GO:43235; receptor complex
GO:5887; integral component of plasma membrane
GO:5901; caveola
GO:5905; clathrin-coated pit
GO:9986; cell surface
And 6 more GO terms
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4675; transmembrane receptor protein serine/threonine kinase activity
GO:5024; transforming growth factor beta-activated receptor activity
GO:36122; BMP binding
And 9 more GO terms
Show all GO terms

Homologs of BMPR2 in Model Organisms

Danio rerio
bmpr2b
Drosophila melanogaster
wit
Mus musculus
Bmpr2
Rattus norvegicus
Bmpr2

External links

OMIM
600799
Ensembl
ENSG00000204217
Entrez Gene
659
UniGene
471119
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BMPR2
GeneCards
BMPR2