Cell Senescence Entries for BRAF

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Michaloglou et al. (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436(7051)720-4 (PubMed)

BRAF Gene Information

HGNC symbol
BRAF 
Aliases
BRAF1 
Common name
B-Raf proto-oncogene, serine/threonine kinase 
Entrez Id
673
Description
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. [provided by RefSeq, Aug 2017].

BRAF Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7165; signal transduction
GO:1934; positive regulation of protein phosphorylation
GO:1902531; regulation of intracellular signal transduction
GO:2318; myeloid progenitor cell differentiation
GO:8542; visual learning
GO:10628; positive regulation of gene expression
GO:10764; negative regulation of fibroblast migration
GO:30154; cell differentiation
GO:30878; thyroid gland development
And 34 more GO terms
Cellular component: GO:43231; intracellular membrane-bounded organelle
GO:5829; cytosol
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5886; plasma membrane
GO:43005; neuron projection
GO:44297; cell body
GO:5634; nucleus
GO:16020; membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3824; catalytic activity
And 7 more GO terms
Show all GO terms

Homologs of BRAF in Model Organisms

Danio rerio
braf
Mus musculus
Braf
Rattus norvegicus
Braf

External links

OMIM
164757
Ensembl
ENSG00000157764
Entrez Gene
673
UniGene
550061
1000 Genomes
1000 Genomes
HPRD
GenAtlas
BRAF
GeneCards
BRAF