The CAPNS1 gene and its putative association with human ageing

Cell Senescence Entries for CAPNS1

Cell Types: Fibroblast
Cell Lines: BJ-ET-Ras
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Oncogene-induced, Stress-induced
Senescence Effect: Induces
Primary Reference: Demarchi et al. (2010) DNA damage response links calpain to cellular senescence. Cell Cycle 9(4)755-60 (PubMed)

HGNC symbol: CAPNS1
Aliases: 30K; CANP; CANPS; CAPN4; CDPS
Common name: calpain small subunit 1
Entrez Id: 826
Description: This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014].

Gene Ontology

Process:

GO:6508; proteolysis
GO:16241; regulation of macroautophagy
GO:8284; positive regulation of cell population proliferation

Cellular component:

GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5829; cytosol
GO:70062; extracellular exosome
GO:110158; calpain complex

Function:

GO:46872; metal ion binding
GO:5509; calcium ion binding
GO:5515; protein binding
GO:4198; calcium-dependent cysteine-type endopeptidase activity

Show all GO terms