Cell Senescence Entries for ACER2

Cell Types
Lung cancer
Cell Lines
H1299
Cancer Cell?
Yes
Method
Knockout, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Xu et al. (2019) Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2. Cell Death Differ 25(5)841-856 (PubMed)

ACER2 Gene Information

HGNC symbol
ACER2 
Aliases
ALKCDase2; ASAH3L; FLJ41587 
Common name
alkaline ceramidase 2 
Entrez Id
340485
Description
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010].

ACER2 Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6665; sphingolipid metabolic process
GO:6974; cellular response to DNA damage stimulus
GO:6672; ceramide metabolic process
GO:8284; positive regulation of cell population proliferation
GO:42981; regulation of apoptotic process
GO:46512; sphingosine biosynthetic process
GO:10506; regulation of autophagy
GO:30148; sphingolipid biosynthetic process
GO:1953; negative regulation of cell-matrix adhesion
GO:30330; DNA damage response, signal transduction by p53 class mediator
And 8 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:139; Golgi membrane
GO:30173; integral component of Golgi membrane
Function: GO:46872; metal ion binding
GO:16787; hydrolase activity
GO:16811; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:17040; N-acylsphingosine amidohydrolase activity
GO:102121; ceramidase activity
GO:71633; dihydroceramidase activity
Show all GO terms

Homologs of ACER2 in Model Organisms

Danio rerio
LOC100331179
Drosophila melanogaster
bwa
Mus musculus
Acer2
Rattus norvegicus
Acer2

In other databases

GenAge microarray genes
  • This gene is present as ACER2

External links

OMIM
613492
Ensembl
ENSG00000177076
Entrez Gene
340485
UniGene
99785
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ACER2
GeneCards
ACER2