Cell Senescence Entries for AAK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

AAK1 Gene Information

HGNC symbol
AAK1 
Aliases
DKFZp686K16132; KIAA1048 
Common name
AP2 associated kinase 1 
Entrez Id
22848
Description
This gene encodes a member of the SNF1 subfamily of serine/threonine protein kinases. Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. The encoded protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. This kinase has been shown to play an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating infection. Inhibitors of this kinase are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Aug 2020].

AAK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6897; endocytosis
GO:46777; protein autophosphorylation
GO:50821; protein stabilization
GO:32880; regulation of protein localization
GO:61024; membrane organization
GO:45747; positive regulation of Notch signaling pathway
GO:2000369; regulation of clathrin-dependent endocytosis
Cellular component: GO:16020; membrane
GO:5905; clathrin-coated pit
GO:5886; plasma membrane
GO:30054; cell junction
GO:42995; cell projection
GO:45202; synapse
GO:5737; cytoplasm
GO:30136; clathrin-coated vesicle
GO:98793; presynapse
GO:5829; cytosol
GO:31252; cell leading edge
And 3 more GO terms
Function: GO:4672; protein kinase activity
GO:5524; ATP binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:5112; Notch binding
GO:35612; AP-2 adaptor complex binding
And 1 more GO terms
Show all GO terms

Homologs of AAK1 in Model Organisms

Caenorhabditis elegans
sel-5
Danio rerio
aak1
Drosophila melanogaster
Nak
Mus musculus
Aak1
Rattus norvegicus
Aak1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as sel-5

External links

OMIM
616405
Ensembl
ENSG00000115977
Entrez Gene
22848
UniGene
468878
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AAK1
GeneCards
AAK1