Cell Senescence Entries for ABI3

Cell Types
Colon cancer, Thyroid cancer
Cell Lines
ARO, WRO
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Latini et al. (2011) ABI3 ectopic expression reduces in vitro and in vivo cell growth properties while inducing senescence. BMC Cancer 11(2)11 (PubMed)

ABI3 Gene Information

HGNC symbol
ABI3 
Aliases
NESH; SSH3BP3 
Common name
ABI family member 3 
Entrez Id
51225
Description
This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

ABI3 Ontologies

Gene Ontology
Process: GO:30334; regulation of cell migration
GO:2357; defense response to tumor cell
GO:2000774; positive regulation of cellular senescence
GO:1903077; negative regulation of protein localization to plasma membrane
GO:61001; regulation of dendritic spine morphogenesis
GO:2000249; regulation of actin cytoskeleton reorganization
GO:10593; negative regulation of lamellipodium assembly
GO:99151; regulation of postsynaptic density assembly
GO:1900028; negative regulation of ruffle assembly
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:30027; lamellipodium
GO:14069; postsynaptic density
GO:43197; dendritic spine
GO:43198; dendritic shaft
GO:31209; SCAR complex
GO:110165; cellular anatomical entity
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:17124; SH3 domain binding
GO:51015; actin filament binding
Show all GO terms

Homologs of ABI3 in Model Organisms

Mus musculus
Abi3
Rattus norvegicus
Abi3

External links

OMIM
606363
Ensembl
ENSG00000108798
Entrez Gene
51225
UniGene
130719
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ABI3
GeneCards
ABI3