Cell Senescence Entries for ABCC6

Cell Types
Liver cancer
Cell Lines
Hep G2
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Miglionico et al. (2017) ABCC6 knockdown in HepG2 cells induces a senescent-like cell phenotype. Cell Mol Biol Lett 22(2)7 (PubMed)

ABCC6 Gene Information

HGNC symbol
ABCC6 
Aliases
ARA; EST349056; MLP1; MRP6; PXE; URG7 
Common name
ATP binding cassette subfamily C member 6 
Entrez Id
368
Description
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008].

ABCC6 Ontologies

Gene Ontology
Process: GO:55085; transmembrane transport
GO:50896; response to stimulus
GO:7601; visual perception
GO:10467; gene expression
GO:71716; leukotriene transport
GO:9410; response to xenobiotic stimulus
GO:15867; ATP transport
GO:46034; ATP metabolic process
GO:55062; phosphate ion homeostasis
GO:55074; calcium ion homeostasis
GO:30505; inorganic diphosphate transport
And 5 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:16323; basolateral plasma membrane
GO:5576; extracellular region
Function: GO:22857; transmembrane transporter activity
GO:166; nucleotide binding
GO:5524; ATP binding
GO:140359; ABC-type transporter activity
GO:42626; ATPase-coupled transmembrane transporter activity
GO:15431; ABC-type glutathione S-conjugate transporter activity
GO:43225; ATPase-coupled inorganic anion transmembrane transporter activity
Show all GO terms

Homologs of ABCC6 in Model Organisms

Mus musculus
Abcc6
Rattus norvegicus
Abcc6
Saccharomyces cerevisiae
YCF1
Schizosaccharomyces pombe
abc3

External links

OMIM
603234
Ensembl
ENSG00000091262
Entrez Gene
368
UniGene
442182
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ABCC6
GeneCards
ABCC6