Cell Senescence Entries for ACKR1

Cell Types
Cerebral-microvascular endothelial
Cell Lines
HCEC
Cancer Cell?
No
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Xu et al. (2008) Duffy antigen/receptor for chemokines (DARC) attenuates angiogenesis by causing senescence in endothelial cells. Angiogenesis 10(4)307-18 (PubMed)

ACKR1 Gene Information

HGNC symbol
ACKR1 
Aliases
CCBP1; CD234; DARC; Dfy; FY; GPD 
Common name
atypical chemokine receptor 1 (Duffy blood group) 
Entrez Id
2532
Description
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

ACKR1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:7186; G protein-coupled receptor signaling pathway
GO:6954; inflammatory response
GO:6952; defense response
GO:70098; chemokine-mediated signaling pathway
GO:32642; regulation of chemokine production
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5768; endosome
GO:5769; early endosome
GO:55037; recycling endosome
GO:5886; plasma membrane
Function: GO:5515; protein binding
GO:4930; G protein-coupled receptor activity
GO:19956; chemokine binding
GO:38023; signaling receptor activity
GO:19957; C-C chemokine binding
GO:4888; transmembrane signaling receptor activity
Show all GO terms

Homologs of ACKR1 in Model Organisms

Mus musculus
Darc

External links

OMIM
613665
Ensembl
ENSG00000213088
Entrez Gene
2532
UniGene
153381
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ACKR1
GeneCards
ACKR1