GenAge entry for C1QA (Homo sapiens)
Gene name (HAGRID: 287)
- HGNC symbol
- C1QA
- Aliases
- Common name
- complement component 1, q subcomponent, A chain
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
C1QA activates Wnt signaling, which has been implicated in mammalian ageing, and promotes ageing-associated decline in tissue regeneration. Serum C1q concentration is increased with ageing, and Wnt signaling activity is augmented during ageing in the serum and in multiple tissues of wild-type mice, but not in C1qa-deficient mice. Skeletal muscle regeneration in young mice is inhibited by exogenous C1q treatment, whereas ageing-associated impairment of muscle regeneration is restored by C1s inhibition or C1qa gene disruption [2228]. C1q protein levels dramatically increase in the normal aging mouse and human brain, by as much as 300-fold, in the hippocampus, substantia nigra, and piriform cortex. Moreover, C1q-deficient mice exhibit less cognitive decline in compared with wild-type mice [3588].
Cytogenetic information
- Cytogenetic band
- 1p36.12
- Location
- 22,636,625 bp to 22,639,682 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006508; proteolysis
GO:0006956; complement activation
GO:0006958; complement activation, classical pathway
GO:0007267; cell-cell signaling
GO:0010039; response to iron ion
GO:0045087; innate immune response
Cellular component: GO:0005576; extracellular region
GO:0005581; collagen trimer
GO:0005602; complement component C1 complex
GO:0070062; extracellular exosome
Hide GO termsFunction: GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
Protein interactions and network
Retrieve sequences for C1QA
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as C1QA