Genes Commonly Altered During Ageing

Entrez Gene ID HGNC symbol Common name Over/Underexpressed Other databases
347APODapolipoprotein DOverexpressed
2213FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)Overexpressed
718C3complement component 3Overexpressed
1191CLUclusterinOverexpressed
1520CTSScathepsin SOverexpressed
4069LYZlysozyme (renal amyloidosis)Overexpressed
3512IGJimmunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptidesOverexpressed
712C1QAcomplement component 1, q subcomponent, A chainOverexpressed
6277S100A6S100 calcium binding protein A6Overexpressed
2670GFAPglial fibrillary acidic proteinOverexpressed
4494MT1Fmetallothionein 1FOverexpressed
713C1QBcomplement component 1, q subcomponent, B chainOverexpressed
3958LGALS3lectin, galactoside-binding, soluble, 3Overexpressed
4257MGST1microsomal glutathione S-transferase 1Overexpressed
306ANXA3annexin A3Overexpressed
308ANXA5annexin A5Overexpressed
6275S100A4S100 calcium binding protein A4Overexpressed
10457GPNMBglycoprotein (transmembrane) nmbOverexpressed
2938GSTA1glutathione S-transferase A1Overexpressed
714C1QCcomplement component 1, q subcomponent, C chainOverexpressed
7450VWFvon Willebrand factorOverexpressed
79139DERL1Der1-like domain family, member 1Overexpressed
10397NDRG1N-myc downstream regulated gene 1Overexpressed
360341Ania4activity and neurotransmitter-induced early gene protein 4 (ania-4)Overexpressed
2212FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)Overexpressed
2634GBP2guanylate binding protein 2, interferon-inducibleOverexpressed
2799GNSglucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID)Overexpressed
90865IL33interleukin 33Overexpressed
219972MPEG1macrophage expressed gene 1Overexpressed
10577NPC2Niemann-Pick disease, type C2Overexpressed
79602ADIPOR2adiponectin receptor 2Overexpressed
567B2Mbeta-2-microglobulinOverexpressed
9516LITAFlipopolysaccharide-induced TNF factorOverexpressed
710SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, (angioedema, hereditary)Overexpressed
10870HCSThematopoietic cell signal transducerOverexpressed
57674RNF213ring finger protein 213Overexpressed
720C4Acomplement component 4A (Rodgers blood group)Overexpressed
6696SPP1secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)Overexpressed
25932CLIC4chloride intracellular channel 4Overexpressed
2202EFEMP1EGF-containing fibulin-like extracellular matrix protein 1Overexpressed
7805LAPTM5lysosomal associated multispanning membrane protein 5Overexpressed
10493VAT1vesicle amine transport protein 1 homolog (T. californica)Overexpressed
3006HIST1H1Chistone cluster 1, H1cOverexpressed
9813KIAA0494KIAA0494Overexpressed
10728PTGES3prostaglandin E synthase 3 (cytosolic)Overexpressed
360231LOC360231MHC class I RT1.O type 149 processed pseudogeneOverexpressed
22821RASA3RAS p21 protein activator 3Overexpressed
5717PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 11Overexpressed
6446SGK1serum/glucocorticoid regulated kinase 1Overexpressed
10628TXNIPthioredoxin interacting proteinOverexpressed
16061Igh-VJ558immunoglobulin heavy chain (J558 family)Overexpressed
3039HBA1hemoglobin, alpha 1Overexpressed
3135HLA-Gmajor histocompatibility complex, class I, GOverexpressed
5046PCSK6proprotein convertase subtilisin/kexin type 6Overexpressed
10972TMED10transmembrane emp24-like trafficking protein 10 (yeast)Overexpressed
4478MSNmoesinOverexpressed
1281COL3A1collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)Underexpressed
7037TFRCtransferrin receptor (p90, CD71)Underexpressed
1277COL1A1collagen, type I, alpha 1Underexpressed
1287COL4A5collagen, type IV, alpha 5 (Alport syndrome)Underexpressed
2170FABP3fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)Underexpressed
518ATP5G3ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)Underexpressed
54539NDUFB11NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDaUnderexpressed
9315C5orf13chromosome 5 open reading frame 13Underexpressed
27089UQCRQubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDaUnderexpressed
436430LOC436430LOC436430 (WITHDRAWN)Underexpressed
793CALB1calbindin 1, 28kDaUnderexpressed
7386UQCRFS1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1Underexpressed
27069GHITMgrowth hormone inducible transmembrane proteinUnderexpressed
55902ACSS2acyl-CoA synthetase short-chain family member 2Underexpressed
56616DIABLOdiablo homolog (Drosophila)Underexpressed
6376CX3CL1chemokine (C-X3-C motif) ligand 1Underexpressed
762CA4carbonic anhydrase IVUnderexpressed

Note: This dataset represents transcriptional signatures of mammalian ageing identifying based on our ageing microarray meta-analysis.