Human Ageing-Associated Genes

HAGRID	HGNC symbol	Common name	Display entry	Source
1	GHR	growth hormone receptor	GHR	mammal
2	GHRH	growth hormone releasing hormone	GHRH	mammal
3	SHC1	SHC (Src homology 2 domain containing) transforming protein 1	SHC1	mammal
4	POU1F1	POU class 1 homeobox 1	POU1F1	mammal
5	PROP1	PROP paired-like homeobox 1	PROP1	mammal
6	TP53	tumor protein p53	TP53	mammal,model,cell
7	TERC	telomerase RNA component	TERC	mammal,cell
8	TERT	telomerase reverse transcriptase	TERT	cell,functional
9	ATM	ATM serine/threonine kinase	ATM	mammal
10	PLAU	plasminogen activator, urokinase	PLAU	mammal
11	ERCC2	excision repair cross-complementation group 2	ERCC2	mammal
12	ERCC8	excision repair cross-complementation group 8	ERCC8	human
13	WRN	Werner syndrome, RecQ helicase-like	WRN	human,mammal,cell
14	LMNA	lamin A/C	LMNA	human
15	IGF1R	insulin-like growth factor 1 receptor	IGF1R	model
16	TXN	thioredoxin	TXN	model,functional
17	KL	klotho	KL	mammal
19	PTPN11	protein tyrosine phosphatase, non-receptor type 11	PTPN11	downstream
20	NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	NFKB2	functional
21	STAT5B	signal transducer and activator of transcription 5B	STAT5B	downstream
22	STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	STAT3	downstream
23	STAT5A	signal transducer and activator of transcription 5A	STAT5A	downstream
26	GH1	growth hormone 1	GH1	mammal,functional,downstream
27	IL7R	interleukin 7 receptor	IL7R	putative
28	IGF1	insulin-like growth factor 1 (somatomedin C)	IGF1	functional
29	IGF2	insulin-like growth factor 2	IGF2	functional
30	INS	insulin	INS	functional
31	NGF	nerve growth factor (beta polypeptide)	NGF	putative
32	IRS1	insulin receptor substrate 1	IRS1	model
33	PTPN1	protein tyrosine phosphatase, non-receptor type 1	PTPN1	downstream
34	IRS2	insulin receptor substrate 2	IRS2	model,putative
35	AKT1	v-akt murine thymoma viral oncogene homolog 1	AKT1	model,cell
36	PIK3CB	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	PIK3CB	model,downstream
37	NGFR	nerve growth factor receptor	NGFR	downstream
38	HRAS	Harvey rat sarcoma viral oncogene homolog	HRAS	model,cell
39	MYC	v-myc avian myelocytomatosis viral oncogene homolog	MYC	cell,upstream
40	EGFR	epidermal growth factor receptor	EGFR	downstream
41	ERBB2	erb-b2 receptor tyrosine kinase 2	ERBB2	downstream
42	INSR	insulin receptor	INSR	model
24	NRG1	neuregulin 1	NRG1	putative
46	IL2	interleukin 2	IL2	putative
47	PDGFB	platelet-derived growth factor beta polypeptide	PDGFB	upstream
48	EGF	epidermal growth factor	EGF	upstream
49	IL2RG	interleukin 2 receptor, gamma	IL2RG	downstream
50	FOS	FBJ murine osteosarcoma viral oncogene homolog	FOS	putative
51	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	PDGFRB	downstream
52	EPOR	Erythropoietin receptor	EPOR	downstream
53	SST	somatostatin	SST	upstream
54	PRKCD	protein kinase C, delta	PRKCD	downstream
55	PPARA	peroxisome proliferator-activated receptor alpha	PPARA	putative
56	RET	ret proto-oncogene	RET	downstream
57	PLCG2	phospholipase C, gamma 2 (phosphatidylinositol-specific)	PLCG2	downstream
58	PEX5	peroxisomal biogenesis factor 5	PEX5	functional
25	HDAC3	histone deacetylase 3	HDAC3	functional
60	PARP1	poly (ADP-ribose) polymerase 1	PARP1	functional,putative
61	BRCA1	breast cancer 1, early onset	BRCA1	mammal
62	PIN1	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	PIN1	upstream
63	PTEN	phosphatase and tensin homolog	PTEN	model
64	CREBBP	CREB binding protein	CREBBP	upstream
65	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	HIF1A	functional,downstream
43	NCOR1	nuclear receptor corepressor 1	NCOR1	downstream
67	RPA1	replication protein A1, 70kDa	RPA1	upstream
68	BLM	Bloom syndrome, RecQ helicase-like	BLM	functional
69	BCL2	B-cell CLL/lymphoma 2	BCL2	functional
70	S100B	S100 calcium binding protein B	S100B	upstream,putative
73	IGFBP3	insulin-like growth factor binding protein 3	IGFBP3	upstream
74	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	HSP90AA1	functional
76	EGR1	early growth response 1	EGR1	upstream
77	VEGFA	vascular endothelial growth factor A	VEGFA	putative
78	ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase	ABL1	functional,downstream
79	BRCA2	breast cancer 2, early onset	BRCA2	functional
80	TOP2A	topoisomerase (DNA) II alpha	TOP2A	functional
81	TOP2B	topoisomerase (DNA) II beta	TOP2B	functional
82	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	NFKB1	functional
83	TOP1	topoisomerase (DNA) I	TOP1	functional
84	RAD51	RAD51 recombinase	RAD51	cell,functional
85	UBE2I	ubiquitin-conjugating enzyme E2I	UBE2I	upstream
86	TNF	tumor necrosis factor	TNF	putative
91	TGFB1	transforming growth factor, beta 1	TGFB1	putative
92	ERCC6	excision repair cross-complementation group 6	ERCC6	functional
93	STK11	serine/threonine kinase 11	STK11	upstream
94	EP300	E1A binding protein p300	EP300	upstream
96	PML	promyelocytic leukemia	PML	cell,downstream
97	GSK3B	glycogen synthase kinase 3 beta	GSK3B	downstream
98	HTT	huntingtin	HTT	mammal
99	PRKCA	protein kinase C, alpha	PRKCA	downstream
100	SSTR3	somatostatin receptor 3	SSTR3	downstream
103	EEF2	eukaryotic translation elongation factor 2	EEF2	putative
104	ERCC3	excision repair cross-complementation group 3	ERCC3	functional
105	TERF1	telomeric repeat binding factor (NIMA-interacting) 1	TERF1	functional
106	PRKDC	protein kinase, DNA-activated, catalytic polypeptide	PRKDC	functional
107	CAT	catalase	CAT	model
109	ERCC5	excision repair cross-complementation group 5	ERCC5	functional
110	AR	androgen receptor	AR	upstream
111	GTF2H2	general transcription factor IIH, polypeptide 2, 44kDa	GTF2H2	downstream
112	XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	XRCC5	mammal
113	PCNA	proliferating cell nuclear antigen	PCNA	functional
114	FEN1	flap structure-specific endonuclease 1	FEN1	downstream
118	POLD1	polymerase (DNA directed), delta 1, catalytic subunit	POLD1	downstream
116	TERF2	telomeric repeat binding factor 2	TERF2	functional
117	XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	XRCC6	functional
199	HSPA8	heat shock 70kDa protein 8	HSPA8	functional
119	BAX	BCL2-associated X protein	BAX	downstream,putative
120	RB1	retinoblastoma 1	RB1	cell
121	EMD	emerin	EMD	functional
122	GRB2	growth factor receptor-bound protein 2	GRB2	downstream
123	FOXO3	forkhead box O3	FOXO3	model,human_link
124	FOXO1	forkhead box O1	FOXO1	model
125	HSF1	heat shock transcription factor 1	HSF1	model
126	XPA	xeroderma pigmentosum, complementation group A	XPA	functional,putative
127	MSRA	methionine sulfoxide reductase A	MSRA	mammal,model
128	RECQL4	RecQ helicase-like 4	RECQL4	functional
129	SOD2	superoxide dismutase 2, mitochondrial	SOD2	mammal,model
130	SOD1	superoxide dismutase 1, soluble	SOD1	model
131	FOXM1	forkhead box M1	FOXM1	functional
132	COQ7	coenzyme Q7 homolog, ubiquinone (yeast)	COQ7	model
133	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	CACNA1A	putative
134	LRP2	low density lipoprotein receptor-related protein 2	LRP2	downstream
135	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	AIFM1	functional
136	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	UCHL1	putative
137	APP	amyloid beta (A4) precursor protein	APP	putative
138	APOE	apolipoprotein E	APOE	human_link
139	A2M	alpha-2-macroglobulin	A2M	putative
141	PRDX1	peroxiredoxin 1	PRDX1	functional,putative
142	PON1	paraoxonase 1	PON1	putative
144	IL6	interleukin 6	IL6	putative
145	RGN	regucalcin	RGN	putative
146	ATP5O	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	ATP5O	model
147	RAD52	RAD52 homolog, DNA repair protein	RAD52	cell,functional
148	TOP3B	topoisomerase (DNA) III beta	TOP3B	functional,putative
149	ERCC1	excision repair cross-complementation group 1	ERCC1	mammal,functional
150	SIRT1	sirtuin 1	SIRT1	mammal,model,cell
151	HDAC1	histone deacetylase 1	HDAC1	functional
153	GPX1	glutathione peroxidase 1	GPX1	functional
154	GSR	glutathione reductase	GSR	functional
155	GSS	glutathione synthetase	GSS	functional
156	GSTA4	glutathione S-transferase alpha 4	GSTA4	functional
157	GSTP1	glutathione S-transferase pi 1	GSTP1	functional
158	MT-CO1	mitochondrially encoded cytochrome c oxidase I	MT-CO1	cell,functional
159	HSPD1	heat shock 60kDa protein 1 (chaperonin)	HSPD1	functional
160	HSPA1A	heat shock 70kDa protein 1A	HSPA1A	mammal,model,functional,putative
161	HSPA1B	heat shock 70kDa protein 1B	HSPA1B	functional,putative
162	PCMT1	protein-L-isoaspartate (D-aspartate) O-methyltransferase	PCMT1	functional,putative
163	MAPK8	mitogen-activated protein kinase 8	MAPK8	model
164	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta	YWHAZ	downstream
165	PTK2B	protein tyrosine kinase 2 beta	PTK2B	downstream
166	PTK2	protein tyrosine kinase 2	PTK2	downstream
167	IL7	interleukin 7	IL7	putative
168	MAPK14	mitogen-activated protein kinase 14	MAPK14	cell,functional
169	FGFR1	fibroblast growth factor receptor 1	FGFR1	putative
170	SP1	Sp1 transcription factor	SP1	upstream
171	FLT1	fms-related tyrosine kinase 1	FLT1	downstream
172	JUN	jun proto-oncogene	JUN	upstream
173	MED1	mediator complex subunit 1	MED1	putative
174	MAPK9	mitogen-activated protein kinase 9	MAPK9	model
175	MAPK3	mitogen-activated protein kinase 3	MAPK3	downstream
176	HMGB1	high mobility group box 1	HMGB1	downstream
177	CCNA2	cyclin A2	CCNA2	downstream
178	HMGB2	high mobility group box 2	HMGB2	downstream
179	MAP3K5	mitogen-activated protein kinase kinase kinase 5	MAP3K5	downstream
115	FAS	Fas cell surface death receptor	FAS	putative
181	LMNB1	lamin B1	LMNB1	functional
182	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	SDHC	model
183	FOXO4	forkhead box O4	FOXO4	model
184	HESX1	HESX homeobox 1	HESX1	upstream
185	PIK3R1	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	PIK3R1	downstream
186	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	BSCL2	putative
187	AGPAT2	1-acylglycerol-3-phosphate O-acyltransferase 2	AGPAT2	putative
188	BMI1	BMI1 proto-oncogene, polycomb ring finger	BMI1	putative
189	EEF1A1	eukaryotic translation elongation factor 1 alpha 1	EEF1A1	model
190	TFAP2A	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	TFAP2A	upstream
191	BDNF	brain-derived neurotrophic factor	BDNF	putative
192	CREB1	cAMP responsive element binding protein 1	CREB1	upstream,putative
193	ATF2	activating transcription factor 2	ATF2	downstream
194	TBP	TATA box binding protein	TBP	upstream
195	APEX1	APEX nuclease (multifunctional DNA repair enzyme) 1	APEX1	functional
196	HBP1	HMG-box transcription factor 1	HBP1	downstream
215	JAK2	Janus kinase 2	JAK2	downstream
198	PTGS2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)	PTGS2	putative
152	HSPA9	heat shock 70kDa protein 9 (mortalin)	HSPA9	model
200	SIN3A	SIN3 transcription regulator family member A	SIN3A	putative
201	CDK1	cyclin-dependent kinase 1	CDK1	downstream
202	TFDP1	transcription factor Dp-1	TFDP1	cell,downstream
18	E2F1	E2F transcription factor 1	E2F1	cell,downstream
206	CTGF	connective tissue growth factor	CTGF	putative
207	HDAC2	histone deacetylase 2	HDAC2	functional,upstream
208	MAX	MYC associated factor X	MAX	functional
209	MXD1	MAX dimerization protein 1	MXD1	functional
210	MDM2	MDM2 proto-oncogene, E3 ubiquitin protein ligase	MDM2	upstream
180	TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	TAF1	downstream
204	POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	POLA1	cell
203	DDIT3	DNA-damage-inducible transcript 3	DDIT3	putative
143	RELA	v-rel avian reticuloendotheliosis viral oncogene homolog A	RELA	functional
71	VCP	valosin containing protein	VCP	downstream
66	UBB	ubiquitin B	UBB	putative
59	TCF3	transcription factor 3	TCF3	putative
45	JUND	jun D proto-oncogene	JUND	mammal,putative
90	MXI1	MAX interactor 1, dimerization protein	MXI1	putative
44	NBN	nibrin	NBN	functional,putative
211	SUMO1	small ubiquitin-like modifier 1	SUMO1	upstream
212	H2AFX	H2A histone family, member X	H2AFX	functional
213	HOXB7	homeobox B7	HOXB7	putative
75	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	NR3C1	downstream
214	HOXC4	homeobox C4	HOXC4	putative
101	HELLS	helicase, lymphoid-specific	HELLS	mammal
72	POLG	polymerase (DNA directed), gamma	POLG	mammal
197	BUB1B	BUB1 mitotic checkpoint serine/threonine kinase B	BUB1B	mammal
140	SNCG	synuclein, gamma (breast cancer-specific protein 1)	SNCG	upstream
95	APTX	aprataxin	APTX	functional
88	CEBPA	CCAAT/enhancer binding protein (C/EBP), alpha	CEBPA	functional
89	CEBPB	CCAAT/enhancer binding protein (C/EBP), beta	CEBPB	mammal
216	ESR1	estrogen receptor 1	ESR1	upstream
217	LEP	leptin	LEP	putative
218	LEPR	leptin receptor	LEPR	putative
219	NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	NFKBIA	mammal,putative
220	CLU	clusterin	CLU	model,putative
221	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	MTOR	mammal,model,cell
222	GHRHR	growth hormone releasing hormone receptor	GHRHR	upstream,putative
223	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	CTNNB1	downstream
224	PSEN1	presenilin 1	PSEN1	putative
225	DLL3	delta-like 3 (Drosophila)	DLL3	putative
226	CDKN2A	cyclin-dependent kinase inhibitor 2A	CDKN2A	mammal,cell
228	DBN1	drebrin 1	DBN1	putative
229	NOG	noggin	NOG	putative
230	ELN	elastin	ELN	human_link
227	PPP1CA	protein phosphatase 1, catalytic subunit, alpha isozyme	PPP1CA	cell,putative
205	MAPT	microtubule-associated protein tau	MAPT	putative
232	UCP3	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3	functional
233	ZMPSTE24	zinc metallopeptidase STE24	ZMPSTE24	upstream,putative
234	TP63	tumor protein p63	TP63	mammal
235	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	UCP2	model
236	POLB	polymerase (DNA directed), beta	POLB	functional
237	GCLC	glutamate-cysteine ligase, catalytic subunit	GCLC	functional
238	GCLM	glutamate-cysteine ligase, modifier subunit	GCLM	model
239	SIRT6	sirtuin 6	SIRT6	mammal
240	BUB3	BUB3 mitotic checkpoint protein	BUB3	mammal
241	RAE1	ribonucleic acid export 1	RAE1	mammal
242	PMCH	pro-melanin-concentrating hormone	PMCH	functional
87	PDPK1	3-phosphoinositide dependent protein kinase 1	PDPK1	downstream
231	ATR	ATR serine/threonine kinase	ATR	mammal
243	MLH1	mutL homolog 1	MLH1	functional,putative
102	APOC3	apolipoprotein C-III	APOC3	putative
244	CSNK1E	casein kinase 1, epsilon	CSNK1E	putative
245	STUB1	STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase	STUB1	mammal
246	PPM1D	protein phosphatase, Mg2+/Mn2+ dependent, 1D	PPM1D	downstream,putative
247	CHEK2	checkpoint kinase 2	CHEK2	functional
248	PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)	PCK1	putative
249	ARHGAP1	Rho GTPase activating protein 1	ARHGAP1	mammal
250	CDC42	cell division cycle 42	CDC42	cell,downstream
251	ARNTL	aryl hydrocarbon receptor nuclear translocator-like	ARNTL	mammal
252	CLOCK	clock circadian regulator	CLOCK	functional,downstream
253	HIC1	hypermethylated in cancer 1	HIC1	upstream
254	PAPPA	pregnancy-associated plasma protein A, pappalysin 1	PAPPA	mammal,functional,putative
255	ADCY5	adenylate cyclase 5	ADCY5	mammal
256	PPARGC1A	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	PPARGC1A	mammal,upstream,downstream
257	GPX4	glutathione peroxidase 4	GPX4	putative
258	UCP1	uncoupling protein 1 (mitochondrial, proton carrier)	UCP1	putative
259	FGF23	fibroblast growth factor 23	FGF23	downstream,putative
260	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	EFEMP1	mammal
261	ERCC4	excision repair cross-complementation group 4	ERCC4	functional,putative
262	CETP	cholesteryl ester transfer protein, plasma	CETP	human_link
263	PPARG	peroxisome proliferator-activated receptor gamma	PPARG	functional
264	AGTR1	angiotensin II receptor, type 1	AGTR1	mammal
265	CISD2	CDGSH iron sulfur domain 2	CISD2	mammal
266	EEF1E1	eukaryotic translation elongation factor 1 epsilon 1	EEF1E1	mammal
267	EPS8	epidermal growth factor receptor pathway substrate 8	EPS8	mammal
268	KCNA3	potassium channel, voltage gated shaker related subfamily A, member 3	KCNA3	mammal
269	SIRT7	sirtuin 7	SIRT7	functional,putative
270	SLC13A1	solute carrier family 13 (sodium/sulfate symporter), member 1	SLC13A1	mammal,model
271	SOCS2	suppressor of cytokine signaling 2	SOCS2	functional,upstream
273	TPP2	tripeptidyl peptidase II	TPP2	mammal
274	TP53BP1	tumor protein p53 binding protein 1	TP53BP1	functional
275	SIRT3	sirtuin 3	SIRT3	functional
276	NCOR2	nuclear receptor corepressor 2	NCOR2	mammal
277	SUN1	Sad1 and UNC84 domain containing 1	SUN1	upstream
278	BAK1	BCL2-antagonist/killer 1	BAK1	functional
279	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	IGFBP2	mammal,functional
280	PYCR1	pyrroline-5-carboxylate reductase 1	PYCR1	putative
281	TP73	tumor protein p73	TP73	functional,putative
282	CNR1	cannabinoid receptor 1 (brain)	CNR1	putative
283	NFE2L2	nuclear factor, erythroid 2-like 2	NFE2L2	cell,upstream
284	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	CDKN1A	cell
285	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	PDGFRA	downstream
286	PIK3CA	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	PIK3CA	upstream
287	C1QA	complement component 1, q subcomponent, A chain	C1QA	upstream
288	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	CDKN2B	cell
289	EIF5A2	eukaryotic translation initiation factor 5A2	EIF5A2	mammal
290	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	MIF	mammal
291	DGAT1	diacylglycerol O-acyltransferase 1	DGAT1	mammal
292	MT1E	metallothionein 1E	MT1E	putative
293	FGF21	fibroblast growth factor 21	FGF21	mammal
294	HTRA2	HtrA serine peptidase 2	HTRA2	mammal
295	GSK3A	glycogen synthase kinase 3 alpha	GSK3A	mammal
296	NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	NUDT1	mammal
297	IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	IKBKB	mammal
298	SQSTM1	sequestosome 1	SQSTM1	putative
299	CDK7	cyclin-dependent kinase 7	CDK7	mammal
300	GRN	granulin	GRN	putative
301	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	SERPINE1	upstream
302	SPRTN	SprT-like N-terminal domain	SPRTN	putative
303	RICTOR	RPTOR independent companion of MTOR, complex 2	RICTOR	functional,putative
304	CTF1	cardiotrophin 1	CTF1	putative
306	TRPV1	transient receptor potential cation channel subfamily V member 1	TRPV1	mammal
307	NFE2L1	nuclear factor, erythroid 2-like 1	NFE2L1	model,functional
305	TRAP1	TNF receptor-associated protein 1	TRAP1	functional,putative
308	IFNB1	Interferon beta	IFNB1	mammal,cell
309	GDF11	growth differentiation factor 11	GDF11	mammal,human_link