GenAge entry for CNR1 (Homo sapiens)

Gene name (HAGRID: 282)

HGNC symbol: CNR1
Aliases: CB1K5; CB-R; CB1; CANN6; CB1A; CNR
Common name: cannabinoid receptor 1 (brain)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: The CNR1 genes encodes for the cannabinoid receptor 1 (CB1) and is involved in cannabinoid-induced central nervous system effects. Mice lacking the Cnr1 gene showed an accelerated age-dependent deficit in spatial learning accompanied by a loss of principal neurons in the hippocampus and enhanced neuroinflammation suggesting that CB1 receptor activity on hippocampal GABAergic neurons protects against age-dependent cognitive decline by reducing pyramidal cell degeneration and neuroinflammation [2206]. In human cells, the CB1 receptors have been linked to neurodegenerative [2207] and macular degeneration [2208]. Genome wide association studies found that genetic variants of CNR1 may be associated with obesity-related phenotypes in humans [2209]. Clearly, CNR1 appears to be related to neurodegenerative diseases, however, its role in broader aspects of ageing is unclear.

Cytogenetic information

Cytogenetic band: 6q14-q15
Location: 88,139,865 bp to 88,166,048 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002866; positive regulation of acute inflammatory response to antigenic stimulus
GO:0007187; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188; adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007283; spermatogenesis
GO:0007413; axonal fasciculation
GO:0007568; aging
GO:0007584; response to nutrient
GO:0007613; memory
GO:0010976; positive regulation of neuron projection development
GO:0019233; sensory perception of pain
GO:0031622; positive regulation of fever generation
GO:0031999; negative regulation of fatty acid beta-oxidation
GO:0032228; regulation of synaptic transmission, GABAergic
GO:0032496; response to lipopolysaccharide
GO:0033004; negative regulation of mast cell activation
GO:0033602; negative regulation of dopamine secretion
GO:0035094; response to nicotine
GO:0038171; cannabinoid signaling pathway
GO:0042220; response to cocaine
GO:0042593; glucose homeostasis
GO:0043065; positive regulation of apoptotic process
GO:0043278; response to morphine
GO:0045471; response to ethanol
GO:0045759; negative regulation of action potential
GO:0045776; negative regulation of blood pressure
GO:0045777; positive regulation of blood pressure
GO:0050796; regulation of insulin secretion
GO:0051001; negative regulation of nitric-oxide synthase activity
GO:0051966; regulation of synaptic transmission, glutamatergic
GO:0060135; maternal process involved in female pregnancy
GO:0060259; regulation of feeding behavior
GO:0060405; regulation of penile erection

Cellular component:

GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0030424; axon
GO:0030426; growth cone
GO:0043231; intracellular membrane-bounded organelle
GO:0045121; membrane raft

Function:

GO:0004949; cannabinoid receptor activity
GO:0008144; drug binding

Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for CNR1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: cnr1
Mus musculus: Cnr1
Rattus norvegicus: Cnr1

In other databases

LongevityMap

This gene is present as CNR1