GenAge entry for EIF5A2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 289)

HGNC symbol: EIF5A2
Aliases
Common name: eukaryotic translation initiation factor 5A2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: A highly conserved gene involved in in translation elongation, EIF5A2 has been associated with cancer [3403]. Its overexpression in mice results in accumulation of chromosomal instability and features resembling accelerated ageing, including a short lifespan, kyphosis, osteoporosis, delay of wound healing and ossification [3246]. Although further studies are needed, EIF5A2 might then play a role in human ageing.

Cytogenetic information

Cytogenetic band: 3q26.2
Location: 170,888,415 bp to 170,908,637 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006452; translational frameshifting
GO:0007283; spermatogenesis
GO:0008284; positive regulation of cell proliferation
GO:0008612; peptidyl-lysine modification to peptidyl-hypusine
GO:0010509; polyamine homeostasis
GO:0015031; protein transport
GO:0045901; positive regulation of translational elongation
GO:0045905; positive regulation of translational termination
GO:0051028; mRNA transport

Cellular component:

GO:0005643; nuclear pore
GO:0005789; endoplasmic reticulum membrane
GO:0005829; cytosol
GO:0043231; intracellular membrane-bounded organelle

Function:

GO:0003746; translation elongation factor activity
GO:0005515; protein binding
GO:0043022; ribosome binding

Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for EIF5A2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: iff-1
Drosophila melanogaster: eIF-5A
Mus musculus: Eif5a2
Rattus norvegicus: Eif5a2
Schizosaccharomyces pombe: tif51b

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as iff-1
A homolog of this gene for Mus musculus is present as Eif5a2