GenAge entry for ERCC5 (Homo sapiens)

Gene name (HAGRID: 109)

HGNC symbol: ERCC5
Aliases: ERCM2; XPGC
Common name: excision repair cross-complementation group 5

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Due to its role in DNA repair in association with the other ERCC proteins, it is possible ERCC5 plays a role in human ageing. Mutations in human ERCC5 cause Xeroderma pigmentosum group G [570], but have also been associated with features of Cockayne syndrome [569].

Cytogenetic information

Cytogenetic band: 13q33
Location: 102,845,841 bp to 102,876,001 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0009411; response to UV
GO:0009650; UV protection
GO:0010225; response to UV-C
GO:0033683; nucleotide-excision repair, DNA incision
GO:0043066; negative regulation of apoptotic process

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005662; DNA replication factor A complex
GO:0005675; holo TFIIH complex
GO:0016591; DNA-directed RNA polymerase II, holoenzyme

Function:

GO:0000405; bubble DNA binding
GO:0003690; double-stranded DNA binding
GO:0003697; single-stranded DNA binding
GO:0004520; endodeoxyribonuclease activity
GO:0005515; protein binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding
GO:0047485; protein N-terminus binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: ERCC2, ERCC6, ERCC3, PCNA, CDK7
STRING interaction network

Retrieve sequences for ERCC5

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: xpg-1
Danio rerio: ercc5
Drosophila melanogaster: mus201
Mus musculus: Ercc5
Rattus norvegicus: Ercc5
Saccharomyces cerevisiae: RAD2
Schizosaccharomyces pombe: rad13

In other databases

LongevityMap

This gene is present as ERCC5