GenAge entry for FGF23 (Homo sapiens)

Gene name (HAGRID: 259)

HGNC symbol: FGF23
Aliases
Common name: fibroblast growth factor 23

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: FGF23-null mice have a short lifespan and develop features resembling premature ageing. This appears to be a vitamin D-mediated process similar to that observed in klohto (KL) mice [1853]. KL has been shown to be an essential cofactor for activation of FGF signaling by FGF23 [1851]. Though inconclusive at present, FGF23 might play some role in ageing.

Cytogenetic information

Cytogenetic band: 12p13.3
Location: 4,368,227 bp to 4,379,728 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0008543; fibroblast growth factor receptor signaling pathway
GO:0010966; regulation of phosphate transport
GO:0010980; positive regulation of vitamin D 24-hydroxylase activity
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0030154; cell differentiation
GO:0030502; negative regulation of bone mineralization
GO:0030643; cellular phosphate ion homeostasis
GO:0032026; response to magnesium ion
GO:0036092; phosphatidylinositol-3-phosphate biosynthetic process
GO:0042369; vitamin D catabolic process
GO:0043547; positive regulation of GTPase activity
GO:0044320; cellular response to leptin stimulus
GO:0045668; negative regulation of osteoblast differentiation
GO:0045893; positive regulation of transcription, DNA-templated
GO:0046854; phosphatidylinositol phosphorylation
GO:0046888; negative regulation of hormone secretion
GO:0048015; phosphatidylinositol-mediated signaling
GO:0055062; phosphate ion homeostasis
GO:0070374; positive regulation of ERK1 and ERK2 cascade
GO:0071305; cellular response to vitamin D
GO:0071354; cellular response to interleukin-6
GO:0071374; cellular response to parathyroid hormone stimulus
GO:0090080; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:1904383; response to sodium phosphate

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005796; Golgi lumen

Function:

GO:0004713; protein tyrosine kinase activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005105; type 1 fibroblast growth factor receptor binding
GO:0008083; growth factor activity
GO:0016303; 1-phosphatidylinositol-3-kinase activity
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: FGFR1
STRING interaction network

Retrieve sequences for FGF23

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: fgf23
Mus musculus: Fgf23
Rattus norvegicus: Fgf23

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Fgf23