GenAge entry for FLT1 (Homo sapiens)

Gene name (HAGRID: 171)

HGNC symbol: FLT1
Aliases: VEGFR1; FLT
Common name: fms-related tyrosine kinase 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Also known as VEGFR1, FLT1 is a receptor for VEGFA involved in its signalling cascade [975]. Mice without FLT1 die at embryonic stages [782]. In mouse skeletal muscle FLT1 expression levels have been reported to decline with age [1624]. FLT1 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band: 13q12
Location: 28,300,346 bp to 28,495,128 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001525; angiogenesis
GO:0002548; monocyte chemotaxis
GO:0007169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284; positive regulation of cell proliferation
GO:0010863; positive regulation of phospholipase C activity
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477; cell migration
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0030154; cell differentiation
GO:0030335; positive regulation of cell migration
GO:0030949; positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924; cellular response to vascular endothelial growth factor stimulus
GO:0036323; vascular endothelial growth factor receptor-1 signaling pathway
GO:0038084; vascular endothelial growth factor signaling pathway
GO:0043406; positive regulation of MAP kinase activity
GO:0043410; positive regulation of MAPK cascade
GO:0043552; positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766; positive regulation of angiogenesis
GO:0046777; protein autophosphorylation
GO:0048010; vascular endothelial growth factor receptor signaling pathway
GO:0048514; blood vessel morphogenesis
GO:0048598; embryonic morphogenesis

Cellular component:

GO:0005615; extracellular space
GO:0005768; endosome
GO:0005886; plasma membrane
GO:0005887; integral component of plasma membrane
GO:0005925; focal adhesion
GO:0043235; receptor complex

Function:

GO:0004714; transmembrane receptor protein tyrosine kinase activity
GO:0005021; vascular endothelial growth factor-activated receptor activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0019838; growth factor binding
GO:0036326; VEGF-A-activated receptor activity
GO:0036327; VEGF-B-activated receptor activity
GO:0036332; placental growth factor-activated receptor activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, PTPN11, VEGFA, PIK3R1
STRING interaction network

Retrieve sequences for FLT1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: flt1
Drosophila melanogaster: Pvr
Mus musculus: Flt1
Rattus norvegicus: Flt1

In other databases

CellAge

This gene is present as FLT1