GenAge entry for GPX1 (Homo sapiens)

Gene name (HAGRID: 153)

HGNC symbol: GPX1
Aliases
Common name: glutathione peroxidase 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Mostly present in erythrocytes, GPX1 protects from oxidative damage. Changes in GPX1 have been reported in mice during ageing and due to caloric restriction [243], but there is no direct evidence linking GPX1 to ageing. Mice without GPX1 are more susceptibility to oxidative stress, but do not show signs of premature ageing [741], except for cataracts [742]. Overexpression of GPX1 in mice results in insulin (INS) resistance and obesity [1066]. Results from transgenic mice overexpressing GPX1 in the heart suggest GPX1 could be beneficial to prevent cardiac failure [1711]. Its role, if any, in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: 3p21.3
Location: 49,357,176 bp to 49,358,358 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000302; response to reactive oxygen species
GO:0001659; temperature homeostasis
GO:0001885; endothelial cell development
GO:0002862; negative regulation of inflammatory response to antigenic stimulus
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0006749; glutathione metabolic process
GO:0007605; sensory perception of sound
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410; response to xenobiotic stimulus
GO:0009609; response to symbiotic bacterium
GO:0009650; UV protection
GO:0010269; response to selenium ion
GO:0010332; response to gamma radiation
GO:0018158; protein oxidation
GO:0019372; lipoxygenase pathway
GO:0033194; response to hydroperoxide
GO:0033599; regulation of mammary gland epithelial cell proliferation
GO:0034599; cellular response to oxidative stress
GO:0040029; regulation of gene expression, epigenetic
GO:0042311; vasodilation
GO:0042542; response to hydrogen peroxide
GO:0042744; hydrogen peroxide catabolic process
GO:0043154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043403; skeletal muscle tissue regeneration
GO:0043523; regulation of neuron apoptotic process
GO:0043534; blood vessel endothelial cell migration
GO:0045444; fat cell differentiation
GO:0045454; cell redox homeostasis
GO:0048741; skeletal muscle fiber development
GO:0051450; myoblast proliferation
GO:0051702; interaction with symbiont
GO:0051897; positive regulation of protein kinase B signaling
GO:0060047; heart contraction
GO:0060055; angiogenesis involved in wound healing
GO:0061136; regulation of proteasomal protein catabolic process
GO:0090201; negative regulation of release of cytochrome c from mitochondria
GO:0098869; cellular oxidant detoxification
GO:1902042; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902176; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902905; positive regulation of supramolecular fiber organization

Cellular component:

GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0070062; extracellular exosome
GO:0097413; Lewy body

Function:

GO:0004602; glutathione peroxidase activity
GO:0017124; SH3 domain binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TXN, ABL1
STRING interaction network

Retrieve sequences for GPX1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gpx-4
Danio rerio: gpx1b
Mus musculus: Gpx1
Rattus norvegicus: Gpx1

In other databases

LongevityMap

This gene is present as GPX1