GenAge entry for GRN (Homo sapiens)
Gene name (HAGRID: 300)
- HGNC symbol
- GRN
- Aliases
- PCDGF; PGRN; CLN11
- Common name
- granulin
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
GRN is an autocrine growth factor. Knockout mice exhibit decreased survival, with less than 50% of animals living more than 2 years, and signs of cellular ageing, though not necessarily progeroid features [3263]. Results from knockout mice also suggest a role for GRN in maintaining neuronal function during ageing [3442]. In humans, GRN mutations have been associated with dementia [3445], but whether GRN is involved in broader aspects of ageing is unknown.
Cytogenetic information
- Cytogenetic band
- 17q21.32
- Location
- 44,345,086 bp to 44,353,106 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0007165; signal transduction
Cellular component: GO:0005615; extracellular space
GO:0043231; intracellular membrane-bounded organelle
GO:0070062; extracellular exosome
Hide GO termsFunction: GO:0005125; cytokine activity
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0044822; poly(A) RNA binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- EGFR, CACNA1A, TOP3B, SIRT3
- STRING interaction network
