GenAge entry for GSTP1 (Homo sapiens)

Gene name (HAGRID: 157)

HGNC symbol: GSTP1
Aliases: GSTP; FAEES3; GST3
Common name: glutathione S-transferase pi 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: GSTP1 is part of the glutathione system involved in oxidative protection [44]. Overexpression of a homologue of GSTP1 in roundworms extended lifespan by about 22% [1548]. There is some evidence linking polymorphisms in the human GSTP1 gene to Parkinson's disease induced by pesticides [750], but GSTP1's role in human ageing remains unknown.

Cytogenetic information

Cytogenetic band: 11q13
Location: 67,583,595 bp to 67,586,653 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000302; response to reactive oxygen species
GO:0002674; negative regulation of acute inflammatory response
GO:0006469; negative regulation of protein kinase activity
GO:0006749; glutathione metabolic process
GO:0006805; xenobiotic metabolic process
GO:0007417; central nervous system development
GO:0009890; negative regulation of biosynthetic process
GO:0010804; negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0014003; oligodendrocyte development
GO:0031100; animal organ regeneration
GO:0032355; response to estradiol
GO:0032691; negative regulation of interleukin-1 beta production
GO:0032720; negative regulation of tumor necrosis factor production
GO:0032869; cellular response to insulin stimulus
GO:0032872; regulation of stress-activated MAPK cascade
GO:0032873; negative regulation of stress-activated MAPK cascade
GO:0032930; positive regulation of superoxide anion generation
GO:0033591; response to L-ascorbic acid
GO:0035726; common myeloid progenitor cell proliferation
GO:0035732; nitric oxide storage
GO:0043066; negative regulation of apoptotic process
GO:0043124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043200; response to amino acid
GO:0043407; negative regulation of MAP kinase activity
GO:0043409; negative regulation of MAPK cascade
GO:0043508; negative regulation of JUN kinase activity
GO:0043651; linoleic acid metabolic process
GO:0045471; response to ethanol
GO:0048147; negative regulation of fibroblast proliferation
GO:0051771; negative regulation of nitric-oxide synthase biosynthetic process
GO:0070372; regulation of ERK1 and ERK2 cascade
GO:0070373; negative regulation of ERK1 and ERK2 cascade
GO:0070664; negative regulation of leukocyte proliferation
GO:0071222; cellular response to lipopolysaccharide
GO:0071364; cellular response to epidermal growth factor stimulus
GO:0071385; cellular response to glucocorticoid stimulus
GO:0071460; cellular response to cell-matrix adhesion
GO:0071638; negative regulation of monocyte chemotactic protein-1 production
GO:0071672; negative regulation of smooth muscle cell chemotaxis
GO:0098869; cellular oxidant detoxification
GO:1901687; glutathione derivative biosynthetic process
GO:1904706; negative regulation of vascular smooth muscle cell proliferation
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway

Cellular component:

GO:0005615; extracellular space
GO:0005622; intracellular
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031982; vesicle
GO:0070062; extracellular exosome
GO:0097057; TRAF2-GSTP1 complex

Function:

GO:0004364; glutathione transferase activity
GO:0004602; glutathione peroxidase activity
GO:0005515; protein binding
GO:0008144; drug binding
GO:0008432; JUN kinase binding
GO:0019207; kinase regulator activity
GO:0035730; S-nitrosoglutathione binding
GO:0035731; dinitrosyl-iron complex binding
GO:0043295; glutathione binding
GO:0070026; nitric oxide binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GSTP1, MAPK8, ATF2, MLH1, SIRT7
STRING interaction network

Retrieve sequences for GSTP1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gst-10
Danio rerio: gstp2
Mus musculus: Gstp2
Rattus norvegicus: Gstp1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as gst-10

LongevityMap

This gene is present as GSTP1