GenAge entry for HESX1 (Homo sapiens)
Gene name (HAGRID: 184)
- HGNC symbol
- HESX1
- Aliases
- RPX; ANF
- Common name
- HESX homeobox 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
HESX1 is an important regulator of development and, particularly, of pituitary development. It may antagonize the transcriptional activities of PROP1 [1726]. Mice without HESX1 develop pituitary dysplasia. Mutations in the human HESX1 gene have been associated with septooptic dysplasia [803]. As a member of the hypothalamus-pituitary system, HESX1 might, in theory, be involved in ageing even if it has so far not been directly associated with human ageing.
Cytogenetic information
- Cytogenetic band
- 3p14.3
- Location
- 57,197,916 bp to 57,200,252 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006351; transcription, DNA-templated
GO:0007420; brain development
GO:0030916; otic vesicle formation
GO:0043584; nose development
GO:0045892; negative regulation of transcription, DNA-templated
GO:0048853; forebrain morphogenesis
Cellular component: GO:0005634; nucleus
Hide GO termsFunction: GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0005515; protein binding
GO:0008022; protein C-terminus binding
GO:0043565; sequence-specific DNA binding
GO:0047485; protein N-terminus binding
