GenAge entry for IGF2 (Homo sapiens)

Gene name (HAGRID: 29)

HGNC symbol: IGF2
Aliases: FLJ44734; IGF-II; C11orf43
Common name: insulin-like growth factor 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Like IGF1, IGF2 is involved in growth and development. Unlike IGF1, IGF2 appears to be only active at early stages of development, such as embryonic growth. IGF2's role in ageing is unproven and its interest derives mostly from its connection with IGF1 and how the IGF1/GH1 axis appears to regulate ageing in model organisms [425]. Mice with disrupted IGF2 are growth-deficient but their lifespan has not been studied [1309]. Polymorphisms in the human IGF2 gene have been associated with body mass index in adult males [1656].

Cytogenetic information

Cytogenetic band: 11p15.5
Location: 2,129,112 bp to 2,138,974 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001501; skeletal system development
GO:0001503; ossification
GO:0001934; positive regulation of protein phosphorylation
GO:0002576; platelet degranulation
GO:0006006; glucose metabolic process
GO:0006349; regulation of gene expression by genetic imprinting
GO:0006355; regulation of transcription, DNA-templated
GO:0007275; multicellular organism development
GO:0008284; positive regulation of cell proliferation
GO:0008286; insulin receptor signaling pathway
GO:0038028; insulin receptor signaling pathway via phosphatidylinositol 3-kinase
GO:0042104; positive regulation of activated T cell proliferation
GO:0043085; positive regulation of catalytic activity
GO:0043410; positive regulation of MAPK cascade
GO:0044267; cellular protein metabolic process
GO:0045725; positive regulation of glycogen biosynthetic process
GO:0045840; positive regulation of mitotic nuclear division
GO:0046628; positive regulation of insulin receptor signaling pathway
GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation
GO:0051781; positive regulation of cell division
GO:0051897; positive regulation of protein kinase B signaling
GO:0071902; positive regulation of protein serine/threonine kinase activity
GO:2000273; positive regulation of receptor activity
GO:2000467; positive regulation of glycogen (starch) synthase activity

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0031093; platelet alpha granule lumen
GO:0070062; extracellular exosome

Function:

GO:0005158; insulin receptor binding
GO:0005159; insulin-like growth factor receptor binding
GO:0005179; hormone activity
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0030546; receptor activator activity
GO:0043539; protein serine/threonine kinase activator activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: IGFBP3
STRING interaction network

Retrieve sequences for IGF2

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: igf2a
Mus musculus: Igf2
Rattus norvegicus: Igf2

In other databases

LongevityMap

This gene is present as IGF2