GenAge entry for IL2 (Homo sapiens)

Gene name (HAGRID: 46)

HGNC symbol: IL2
Aliases: IL-2; TCGF
Common name: interleukin 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: IL2 is a cytokine that has been associated with age-related changes at the immune system level [369]. Studies of polymorphisms in the human IL2 gene, however, have so far failed to find an association with human longevity [222].

Cytogenetic information

Cytogenetic band: 4q26-q27
Location: 122,451,471 bp to 122,456,495 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0001933; negative regulation of protein phosphorylation
GO:0002250; adaptive immune response
GO:0002903; negative regulation of B cell apoptotic process
GO:0006955; immune response
GO:0007155; cell adhesion
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007205; protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0030101; natural killer cell activation
GO:0030217; T cell differentiation
GO:0030307; positive regulation of cell growth
GO:0030890; positive regulation of B cell proliferation
GO:0032729; positive regulation of interferon-gamma production
GO:0032740; positive regulation of interleukin-17 production
GO:0034105; positive regulation of tissue remodeling
GO:0042104; positive regulation of activated T cell proliferation
GO:0042523; positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0043066; negative regulation of apoptotic process
GO:0043547; positive regulation of GTPase activity
GO:0045471; response to ethanol
GO:0045591; positive regulation of regulatory T cell differentiation
GO:0045822; negative regulation of heart contraction
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046013; regulation of T cell homeostatic proliferation
GO:0048304; positive regulation of isotype switching to IgG isotypes
GO:0050672; negative regulation of lymphocyte proliferation
GO:0050728; negative regulation of inflammatory response
GO:0050729; positive regulation of inflammatory response
GO:0051024; positive regulation of immunoglobulin secretion
GO:0060999; positive regulation of dendritic spine development
GO:0097192; extrinsic apoptotic signaling pathway in absence of ligand

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005622; intracellular

Function:

GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005125; cytokine activity
GO:0005134; interleukin-2 receptor binding
GO:0008083; growth factor activity
GO:0019209; kinase activator activity
GO:0030246; carbohydrate binding
GO:0031851; kappa-type opioid receptor binding
GO:0043208; glycosphingolipid binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: IL2RG
STRING interaction network

Retrieve sequences for IL2

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Il2
Rattus norvegicus: Il2

In other databases

LongevityMap

This gene is present as IL2