GenAge entry for IL7R (Homo sapiens)

Gene name (HAGRID: 27)

HGNC symbol: IL7R
Aliases: CD127
Common name: interleukin 7 receptor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: IL7R is involved in inflammation and immune response. Though a role in human ageing has not been demonstrated, it is possible that IL7R is related to age-related changes and pathologies, namely, at the level of the immune system [296].

Cytogenetic information

Cytogenetic band: 5p13
Location: 35,856,875 bp to 35,879,603 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000018; regulation of DNA recombination
GO:0000902; cell morphogenesis
GO:0001915; negative regulation of T cell mediated cytotoxicity
GO:0002377; immunoglobulin production
GO:0006955; immune response
GO:0007165; signal transduction
GO:0007166; cell surface receptor signaling pathway
GO:0008361; regulation of cell size
GO:0010628; positive regulation of gene expression
GO:0016049; cell growth
GO:0030217; T cell differentiation
GO:0033089; positive regulation of T cell differentiation in thymus
GO:0038111; interleukin-7-mediated signaling pathway
GO:0042100; B cell proliferation
GO:0048535; lymph node development
GO:0048872; homeostasis of number of cells

Cellular component:

GO:0005576; extracellular region
GO:0005886; plasma membrane
GO:0009897; external side of plasma membrane
GO:0016021; integral component of membrane

Function:

GO:0003823; antigen binding
GO:0004917; interleukin-7 receptor activity
GO:0005515; protein binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TOP1, PTK2B
STRING interaction network

Retrieve sequences for IL7R

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: il7r
Mus musculus: Il7r
Rattus norvegicus: Il7r