GenAge entry for LEPR (Homo sapiens)

Gene name (HAGRID: 218)

HGNC symbol: LEPR
Aliases: OBR; CD295
Common name: leptin receptor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: LEPR is the receptor for leptin (LEP) and is involved in LEP's signal transduction [1221]. The obese spontaneously hypertensive Koletsky rat has been associated with mutations in LEPR [217]. Deletion of LEPR in neurons of mice results in obesity [1742]. Polymorphisms in the human LEPR gene have been associated with obesity, body mass index, and fat mass [1745]. Like LEP, LEPR plays a role in fat metabolism and so could be involved in some aspects of age-related deterioration.

Cytogenetic information

Cytogenetic band: 1p31
Location: 65,420,652 bp to 65,637,493 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001525; angiogenesis
GO:0006112; energy reserve metabolic process
GO:0006909; phagocytosis
GO:0007166; cell surface receptor signaling pathway
GO:0007275; multicellular organism development
GO:0008203; cholesterol metabolic process
GO:0010507; negative regulation of autophagy
GO:0019953; sexual reproduction
GO:0030217; T cell differentiation
GO:0033210; leptin-mediated signaling pathway
GO:0042593; glucose homeostasis
GO:0044321; response to leptin
GO:0045721; negative regulation of gluconeogenesis
GO:0046850; regulation of bone remodeling
GO:0051346; negative regulation of hydrolase activity
GO:0060259; regulation of feeding behavior
GO:0097009; energy homeostasis
GO:0098868; bone growth
GO:2000505; regulation of energy homeostasis

Cellular component:

GO:0005576; extracellular region
GO:0005886; plasma membrane
GO:0016021; integral component of membrane
GO:0016323; basolateral plasma membrane
GO:0043235; receptor complex

Function:

GO:0004888; transmembrane signaling receptor activity
GO:0005515; protein binding
GO:0038021; leptin receptor activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PIN1
STRING interaction network

Retrieve sequences for LEPR

ORF: ORF
CDS: CDS

Homologs in model organisms

No homologs found

In other databases

LongevityMap

This gene is present as LEPR