GenAge entry for NOG (Homo sapiens)
Gene name (HAGRID: 229)
- HGNC symbol
- NOG
- Aliases
- SYNS1; SYM1
- Common name
- noggin
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
NOG appears to be involved in development, though its exact functions remain unclear. Mice without NOG die shortly after birth [1417]. Overexpression of NOG in mice resulted in severe osteoporosis [1412]. Mutations in the human NOG gene affect joint morphogenesis [1415]. NOG may be a factor in bone ageing, but its role in human ageing remains to be established.
Cytogenetic information
- Cytogenetic band
- 17q22
- Location
- 56,593,699 bp to 56,595,590 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001501; skeletal system development
GO:0001649; osteoblast differentiation
GO:0001701; in utero embryonic development
GO:0001706; endoderm formation
GO:0001707; mesoderm formation
GO:0001837; epithelial to mesenchymal transition
GO:0001839; neural plate morphogenesis
GO:0001843; neural tube closure
GO:0003149; membranous septum morphogenesis
GO:0003151; outflow tract morphogenesis
GO:0003203; endocardial cushion morphogenesis
GO:0003223; ventricular compact myocardium morphogenesis
GO:0007399; nervous system development
GO:0008045; motor neuron axon guidance
GO:0009953; dorsal/ventral pattern formation
GO:0010628; positive regulation of gene expression
GO:0021510; spinal cord development
GO:0021533; cell differentiation in hindbrain
GO:0021983; pituitary gland development
GO:0030336; negative regulation of cell migration
GO:0030509; BMP signaling pathway
GO:0030514; negative regulation of BMP signaling pathway
GO:0035019; somatic stem cell population maintenance
GO:0042060; wound healing
GO:0042474; middle ear morphogenesis
GO:0042733; embryonic digit morphogenesis
GO:0045668; negative regulation of osteoblast differentiation
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0048318; axial mesoderm development
GO:0048570; notochord morphogenesis
GO:0048706; embryonic skeletal system development
GO:0048712; negative regulation of astrocyte differentiation
GO:0050679; positive regulation of epithelial cell proliferation
GO:0051216; cartilage development
GO:0055009; atrial cardiac muscle tissue morphogenesis
GO:0060044; negative regulation of cardiac muscle cell proliferation
GO:0060173; limb development
GO:0060272; embryonic skeletal joint morphogenesis
GO:0060302; negative regulation of cytokine activity
GO:0060325; face morphogenesis
GO:0060394; negative regulation of pathway-restricted SMAD protein phosphorylation
GO:0060412; ventricular septum morphogenesis
GO:0060425; lung morphogenesis
GO:0060513; prostatic bud formation
GO:0060676; ureteric bud formation
GO:0060825; fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0061037; negative regulation of cartilage development
GO:0061053; somite development
GO:0061312; BMP signaling pathway involved in heart development
GO:0061384; heart trabecula morphogenesis
GO:0061626; pharyngeal arch artery morphogenesis
GO:0090090; negative regulation of canonical Wnt signaling pathway
GO:0090190; positive regulation of branching involved in ureteric bud morphogenesis
GO:0090193; positive regulation of glomerulus development
GO:1905006; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
GO:2000313; regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:2001234; negative regulation of apoptotic signaling pathway
Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
Hide GO termsFunction: GO:0005515; protein binding
GO:0019955; cytokine binding
GO:0042803; protein homodimerization activity
