GenAge entry for NRG1 (Homo sapiens)

Gene name (HAGRID: 24)

HGNC symbol: NRG1
Aliases: HRG; NDF; GGF; HGL; NRG1-IT2
Common name: neuregulin 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: The NRG1 gene encodes multiple transcripts that appear to play a role in neuronal development, differentiation, and apoptosis [272]. It may be involved in neurodegenerative pathologies [1297], but it is unknown whether it plays a role in human ageing.

Cytogenetic information

Cytogenetic band: 8p12
Location: 32,646,732 bp to 32,743,252 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0000187; activation of MAPK activity
GO:0000902; cell morphogenesis
GO:0001964; startle response
GO:0003161; cardiac conduction system development
GO:0003222; ventricular trabecula myocardium morphogenesis
GO:0007154; cell communication
GO:0007171; activation of transmembrane receptor protein tyrosine kinase activity
GO:0007399; nervous system development
GO:0007416; synapse assembly
GO:0007422; peripheral nervous system development
GO:0007626; locomotory behavior
GO:0008284; positive regulation of cell proliferation
GO:0008366; axon ensheathment
GO:0009790; embryo development
GO:0014032; neural crest cell development
GO:0014066; regulation of phosphatidylinositol 3-kinase signaling
GO:0014068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108; peptidyl-tyrosine phosphorylation
GO:0021781; glial cell fate commitment
GO:0021842; chemorepulsion involved in interneuron migration from the subpallium to the cortex
GO:0030879; mammary gland development
GO:0031643; positive regulation of myelination
GO:0032148; activation of protein kinase B activity
GO:0035556; intracellular signal transduction
GO:0038127; ERBB signaling pathway
GO:0038128; ERBB2 signaling pathway
GO:0042060; wound healing
GO:0042177; negative regulation of protein catabolic process
GO:0043496; regulation of protein homodimerization activity
GO:0043497; regulation of protein heterodimerization activity
GO:0043547; positive regulation of GTPase activity
GO:0045213; neurotransmitter receptor metabolic process
GO:0045773; positive regulation of axon extension
GO:0045892; negative regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046579; positive regulation of Ras protein signal transduction
GO:0046854; phosphatidylinositol phosphorylation
GO:0048015; phosphatidylinositol-mediated signaling
GO:0048663; neuron fate commitment
GO:0048709; oligodendrocyte differentiation
GO:0050731; positive regulation of peptidyl-tyrosine phosphorylation
GO:0051048; negative regulation of secretion
GO:0051155; positive regulation of striated muscle cell differentiation
GO:0051897; positive regulation of protein kinase B signaling
GO:0055007; cardiac muscle cell differentiation
GO:0060379; cardiac muscle cell myoblast differentiation
GO:0060956; endocardial cell differentiation
GO:0060999; positive regulation of dendritic spine development
GO:0070886; positive regulation of calcineurin-NFAT signaling cascade
GO:1903955; positive regulation of protein targeting to mitochondrion
GO:2000010; positive regulation of protein localization to cell surface
GO:2000145; regulation of cell motility
GO:2000727; positive regulation of cardiac muscle cell differentiation
GO:2001223; negative regulation of neuron migration

Cellular component:

GO:0005576; extracellular region
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005887; integral component of plasma membrane
GO:0009897; external side of plasma membrane
GO:0016020; membrane
GO:0030425; dendrite
GO:0030673; axolemma
GO:0031594; neuromuscular junction
GO:0044297; cell body

Function:

GO:0003712; transcription cofactor activity
GO:0004713; protein tyrosine kinase activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005125; cytokine activity
GO:0005176; ErbB-2 class receptor binding
GO:0005178; integrin binding
GO:0008083; growth factor activity
GO:0030297; transmembrane receptor protein tyrosine kinase activator activity
GO:0030971; receptor tyrosine kinase binding
GO:0043125; ErbB-3 class receptor binding
GO:0045499; chemorepellent activity
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: EGFR, ERBB2, CISD2
STRING interaction network

Retrieve sequences for NRG1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: nrg1
Mus musculus: Nrg1
Rattus norvegicus: Nrg1