GenAge entry for NUDT1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 296)

HGNC symbol: NUDT1
Aliases: MTH1
Common name: nudix (nucleoside diphosphate linked moiety X)-type motif 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: NUDT1 degrades oxidative damage to DNA and RNA. Mice defective in NUDT1 develop spontaneous tumours [3430]. Mice overexpressing human NUDT1 have lower levels of DNA damage and live 16% longer [3257], suggesting a role in ageing. Further studies are necessary, however.

Cytogenetic information

Cytogenetic band: 7p22
Location: 2,242,221 bp to 2,251,145 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006195; purine nucleotide catabolic process
GO:0006203; dGTP catabolic process
GO:0006281; DNA repair
GO:0006979; response to oxidative stress
GO:0007568; aging
GO:0008584; male gonad development
GO:0034656; nucleobase-containing small molecule catabolic process
GO:0042262; DNA protection
GO:0046061; dATP catabolic process
GO:0046686; response to cadmium ion

Cellular component:

GO:0001669; acrosomal vesicle
GO:0005615; extracellular space
GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0031965; nuclear membrane
GO:0070062; extracellular exosome

Function:

GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0008413; 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
GO:0030515; snoRNA binding
GO:0035539; 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
GO:0036219; GTP diphosphatase activity
GO:0044713; 2-hydroxy-adenosine triphosphate pyrophosphatase activity
GO:0044714; 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
GO:0046872; metal ion binding
GO:0047693; ATP diphosphatase activity
GO:0050072; m7G(5')pppN diphosphatase activity

Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for NUDT1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: nudt1
Mus musculus: Nudt1
Rattus norvegicus: Nudt1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as NUDT1

CellAge gene expression

This gene is present as NUDT1