GenAge entry for PLAU (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 10)

HGNC symbol: PLAU
Aliases: URK; UPA
Common name: plasminogen activator, urokinase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: PLAU is a protease that converts plasminogen to plasmin. It appears to affect murine ageing: its overexpression in the brain diminishes food consumption and extends longevity probably through a mechanism similar to caloric restriction [13]. It is unclear at present whether PLAU affects human ageing, despite some evidence linking PLAU to age-related neurological diseases [374].

Cytogenetic information

Cytogenetic band: 10q22.2
Location: 73,911,104 bp to 73,917,500 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001666; response to hypoxia
GO:0006508; proteolysis
GO:0006935; chemotaxis
GO:0007165; signal transduction
GO:0007596; blood coagulation
GO:0010469; regulation of receptor activity
GO:0014909; smooth muscle cell migration
GO:0014910; regulation of smooth muscle cell migration
GO:0030335; positive regulation of cell migration
GO:0033628; regulation of cell adhesion mediated by integrin
GO:0042127; regulation of cell proliferation
GO:0042730; fibrinolysis
GO:0061041; regulation of wound healing
GO:2000097; regulation of smooth muscle cell-matrix adhesion

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0009986; cell surface
GO:0070062; extracellular exosome

Function:

GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: HRAS, MYC, LRP2, SERPINE1
STRING interaction network

Retrieve sequences for PLAU

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: plaua
Mus musculus: Plau
Rattus norvegicus: Plau

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Plau