GenAge entry for POLD1 (Homo sapiens)

Gene name (HAGRID: 118)

HGNC symbol: POLD1
Aliases: CDC2; POLD
Common name: polymerase (DNA directed), delta 1, catalytic subunit

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: POLD1 is mostly involved in DNA synthesis, and probably it also functions in DNA repair [920]. Mice with a proofreading-deficient version of POLD1 have a higher cancer incidence [917]. POLD1 has also been associated with WRN [922]. There is no direct evidence linking POLD1 to human ageing, but it should be considered a suspect gene.

Cytogenetic information

Cytogenetic band: 19q13.3
Location: 50,384,323 bp to 50,418,018 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000722; telomere maintenance via recombination
GO:0000723; telomere maintenance
GO:0000731; DNA synthesis involved in DNA repair
GO:0006260; DNA replication
GO:0006271; DNA strand elongation involved in DNA replication
GO:0006281; DNA repair
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006287; base-excision repair, gap-filling
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006297; nucleotide-excision repair, DNA gap filling
GO:0006298; mismatch repair
GO:0009411; response to UV
GO:0019985; translesion synthesis
GO:0033683; nucleotide-excision repair, DNA incision
GO:0034644; cellular response to UV
GO:0042769; DNA damage response, detection of DNA damage
GO:0045004; DNA replication proofreading
GO:0055089; fatty acid homeostasis

Cellular component:

GO:0000109; nucleotide-excision repair complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0016020; membrane
GO:0016235; aggresome
GO:0043625; delta DNA polymerase complex

Function:

GO:0000166; nucleotide binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003684; damaged DNA binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0005515; protein binding
GO:0008296; 3'-5'-exodeoxyribonuclease activity
GO:0019899; enzyme binding
GO:0046872; metal ion binding
GO:0051539; 4 iron, 4 sulfur cluster binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: MYC, RPA1, ERCC6, PCNA, TERF2, ATR, SPRTN
STRING interaction network

Retrieve sequences for POLD1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: F10C2.4
Danio rerio: pold1
Drosophila melanogaster: DNApol-delta
Mus musculus: Pold1
Rattus norvegicus: Pold1
Saccharomyces cerevisiae: POL3
Schizosaccharomyces pombe: pol3

In other databases

LongevityMap

This gene is present as POLD1

CellAge gene expression

This gene is present as POLD1