GenAge entry for POLG (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 72)

HGNC symbol: POLG
Aliases: POLG1; POLGA
Common name: polymerase (DNA directed), gamma

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: POLG is involved in mitochondrial DNA replication and repair [1060]. Mice with a proof-reading-deficient version of POLG display signs of premature ageing starting at about 25 weeks of age [1059]. Although the exact molecular and cellular events responsible for such phenotype are not clear, they could involve the accumulation of mitochondrial DNA mutations and an increased apoptosis [1466]. In humans, mutations in POLG have been associated with CNS diseases [1055]. Further studies are necessary to determine whether POLG plays a role in human ageing.

Cytogenetic information

Cytogenetic band: 15q25
Location: 89,316,305 bp to 89,334,795 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006259; DNA metabolic process
GO:0006261; DNA-dependent DNA replication
GO:0006264; mitochondrial DNA replication
GO:0006287; base-excision repair, gap-filling
GO:0007568; aging
GO:0009416; response to light stimulus
GO:0010332; response to gamma radiation
GO:0055093; response to hyperoxia
GO:0071333; cellular response to glucose stimulus
GO:0071897; DNA biosynthetic process
GO:0090305; nucleic acid phosphodiester bond hydrolysis

Cellular component:

GO:0005739; mitochondrion
GO:0005760; gamma DNA polymerase complex
GO:0042645; mitochondrial nucleoid
GO:0043195; terminal bouton
GO:0043234; protein complex
GO:0070062; extracellular exosome

Function:

GO:0002020; protease binding
GO:0003677; DNA binding
GO:0003682; chromatin binding
GO:0003887; DNA-directed DNA polymerase activity
GO:0005515; protein binding
GO:0008408; 3'-5' exonuclease activity

Hide GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for POLG

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: polg-1
Danio rerio: polg
Drosophila melanogaster: tam
Mus musculus: Polg
Rattus norvegicus: Polg
Saccharomyces cerevisiae: MIP1

In other databases

LongevityMap

This gene is present as POLG