GenAge entry for SNCG (Homo sapiens)
Gene name (HAGRID: 140)
- HGNC symbol
- SNCG
- Aliases
- BCSG1; SR; persyn
- Common name
- synuclein, gamma (breast cancer-specific protein 1)
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
SNCG is a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. SNCG also appears to regulate BUB1B [1702]. While SNCG has been linked to cancer and CNS development [1083], its role, if any, in human ageing is unknown.
Cytogenetic information
- Cytogenetic band
- 10q23.2-q2
- Location
- 86,958,531 bp to 86,963,260 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0007268; chemical synaptic transmission
GO:0008344; adult locomotory behavior
GO:0009306; protein secretion
GO:0014059; regulation of dopamine secretion
GO:0046928; regulation of neurotransmitter secretion
GO:0050808; synapse organization
Cellular component: GO:0005737; cytoplasm
GO:0005815; microtubule organizing center
GO:0005819; spindle
GO:0030424; axon
GO:0043025; neuronal cell body
GO:0048471; perinuclear region of cytoplasm
GO:0070062; extracellular exosome
Hide GO termsFunction: GO:0005515; protein binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- TERF1, MAPK8, MAPK3, BUB1B
- STRING interaction network
