GenAge entry for UCP3 (Homo sapiens)

Gene name (HAGRID: 232)

HGNC symbol: UCP3
Aliases: SLC25A9
Common name: uncoupling protein 3 (mitochondrial, proton carrier)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Mitochondrial uncoupling proteins create proton leaks across the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis resulting in energy being dissipated as heat. UCP3, whose gene has two splice variants, appears thus to be involved in thermogenesis. Some results from mice suggest that UCP3 might protect against oxidative damage [1449]. Mice overexpressing UCP3 in skeletal muscle are hyperphagic and lean [1456]. UCP3-null mice were normal, though production of reactive oxygen species was increased in mitochondria [1458]. Polymorphisms in the human UCP3 gene could be related to obesity and type 2 diabetes [1459].

Cytogenetic information

Cytogenetic band: 11q13.4
Location: 74,000,281 bp to 74,009,237 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000303; response to superoxide
GO:0001666; response to hypoxia
GO:0006629; lipid metabolic process
GO:0006631; fatty acid metabolic process
GO:0006839; mitochondrial transport
GO:0007568; aging
GO:0007584; response to nutrient
GO:0007585; respiratory gaseous exchange
GO:0009409; response to cold
GO:0014823; response to activity
GO:0015992; proton transport
GO:0032868; response to insulin
GO:0032870; cellular response to hormone stimulus
GO:0051384; response to glucocorticoid

Cellular component:

GO:0005739; mitochondrion
GO:0005743; mitochondrial inner membrane
GO:0016021; integral component of membrane

Function:

GO:0005215; transporter activity
GO:0005515; protein binding
GO:0017077; oxidative phosphorylation uncoupler activity

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: YWHAZ
STRING interaction network

Retrieve sequences for UCP3

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Ucp3
Rattus norvegicus: Ucp3

In other databases

LongevityMap

This gene is present as UCP3