GenAge entry for XPA (Homo sapiens)

Gene name (HAGRID: 126)

HGNC symbol: XPA
Aliases: XPAC; XP1
Common name: xeroderma pigmentosum, complementation group A

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: XPA is primarily involved in DNA repair. In mice, mutations in both XPA and ERCC2 result in a phenotype resembling accelerated ageing with animals living about 5 months, but because mutations in ERCC2 alone also result in accelerated ageing, it is not clear to what extent the XPA gene contributes to the accelerated ageing phenotype [14]. In fact, mice lacking XPA do not appear to age faster [494]. Mice mutant for XPA and ERCC6 die before weaning and display some signs of premature ageing included stunted growth, neurological dysfunction, retinal degeneration, cachexia, and kyphosis [1934]. In humans, XPA has been associated with cancer [396], though it is possible XPA also plays some role in human ageing.

Cytogenetic information

Cytogenetic band: 9q22.3
Location: 97,674,909 bp to 97,697,409 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000715; nucleotide-excision repair, DNA damage recognition
GO:0000717; nucleotide-excision repair, DNA duplex unwinding
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006284; base-excision repair
GO:0006293; nucleotide-excision repair, preincision complex stabilization
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006295; nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296; nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006979; response to oxidative stress
GO:0008630; intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009636; response to toxic substance
GO:0010996; response to auditory stimulus
GO:0033683; nucleotide-excision repair, DNA incision
GO:0035264; multicellular organism growth
GO:0070911; global genome nucleotide-excision repair
GO:0070914; UV-damage excision repair
GO:1901255; nucleotide-excision repair involved in interstrand cross-link repair

Cellular component:

GO:0000110; nucleotide-excision repair factor 1 complex
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005662; DNA replication factor A complex
GO:0005737; cytoplasm
GO:0005794; Golgi apparatus
GO:0045171; intercellular bridge

Function:

GO:0003684; damaged DNA binding
GO:0005515; protein binding
GO:0019904; protein domain specific binding
GO:0042803; protein homodimerization activity
GO:0046872; metal ion binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: ATM, RPA1, ERCC6, EP300, PRKDC, ERCC1, HMGB1, ATR, ERCC4
STRING interaction network

Retrieve sequences for XPA

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: xpa-1
Drosophila melanogaster: Xpac
Mus musculus: Xpa
Rattus norvegicus: Xpa
Saccharomyces cerevisiae: RAD14
Schizosaccharomyces pombe: rhp14

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Xpa

LongevityMap

This gene is present as XPA