GenAge entry for ZMPSTE24 (Homo sapiens)
Gene name (HAGRID: 233)
- HGNC symbol
- ZMPSTE24
- Aliases
- FACE-1; Ste24p; STE24; HGPS; PRO1
- Common name
- zinc metallopeptidase STE24
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
- Description
ZMPSTE24 is a zinc metalloprotease involved in the post-translational processing of LMNA precursors. ZMPSTE24-null mice have a short lifespan and show some signs of accelerated ageing. Disruption of TP53 in ZMPSTE24-null mice partly alleviates these symptoms [1472]. Mutations in ZMPSTE24 have been associated with human diseases, often due to the accumulation of LMNA precursors [1477]. It is possible that ZMPSTE24, maybe due to its association with LMNA, plays some role in human ageing.
Cytogenetic information
- Cytogenetic band
- 1p34
- Location
- 40,258,050 bp to 40,294,184 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0006508; proteolysis
GO:0006998; nuclear envelope organization
GO:0030327; prenylated protein catabolic process
GO:0071586; CAAX-box protein processing
Cellular component: GO:0005637; nuclear inner membrane
GO:0016020; membrane
GO:0030176; integral component of endoplasmic reticulum membrane
GO:0070062; extracellular exosome
Hide GO termsFunction: GO:0004222; metalloendopeptidase activity
GO:0008235; metalloexopeptidase activity
GO:0046872; metal ion binding
Protein interactions and network
Retrieve sequences for ZMPSTE24
Homologs in model organisms
- Caenorhabditis elegans
- fce-1
- Danio rerio
- zmpste24
- Drosophila melanogaster
- ste24a
- Mus musculus
- Zmpste24
- Rattus norvegicus
- Zmpste24
- Saccharomyces cerevisiae
- STE24
- Schizosaccharomyces pombe
- SPAC3H1.05
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Zmpste24
- CellAge
- This gene is present as ZMPSTE24