GenAge entry for AGPAT2 (Homo sapiens)
Gene name (HAGRID: 187)
- HGNC symbol
- AGPAT2
- Aliases
- LPAAT-beta; BSCL
- Common name
- 1-acylglycerol-3-phosphate O-acyltransferase 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
AGPAT2 is a phospholipid with diverse biologic activities. Mutations in the human AGPAT2 gene have been associated with Bernardinelli-Seip congenital lipodystrophy, a possible segmental progeroid syndrome [151].
Cytogenetic information
- Cytogenetic band
- 9q34.3
- Location
- 136,673,143 bp to 136,687,459 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0001819; positive regulation of cytokine production
GO:0001961; positive regulation of cytokine-mediated signaling pathway
GO:0006644; phospholipid metabolic process
GO:0006654; phosphatidic acid biosynthetic process
GO:0008544; epidermis development
GO:0016024; CDP-diacylglycerol biosynthetic process
GO:0019432; triglyceride biosynthetic process
GO:0042493; response to drug
Cellular component: GO:0005783; endoplasmic reticulum
GO:0005789; endoplasmic reticulum membrane
GO:0016021; integral component of membrane
Show all GO termsFunction: GO:0003841; 1-acylglycerol-3-phosphate O-acyltransferase activity
Protein interactions and network
No interactions in records.
Retrieve sequences for AGPAT2
Homologs in model organisms
- Caenorhabditis elegans
- acl-2
- Drosophila melanogaster
- CG3812
- Mus musculus
- Agpat2
- Rattus norvegicus
- Agpat2
- Saccharomyces cerevisiae
- SLC1