GenAge entry for APOC3 (Homo sapiens)

Gene name (HAGRID: 102)

HGNC symbol: APOC3
Aliases
Common name: apolipoprotein C-III

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: APOC3 is involved in fat metabolism and may delay the catabolism of triglyceride-rich particles. Changes in APOC3 expression levels have been reported in aged mice [1754]. Results from mice suggest that FOXO1 may regulate the expression of APOC3 [1743]. Polymorphisms in the human APOC3 gene and promoter have been associated with lipoprotein profile, cardiovascular health, insulin (INS) sensitivity, and longevity [1756]. Therefore, APOC3 may impact on some age-related diseases, though its exact role in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: 11q23.3
Location: 116,829,908 bp to 116,833,071 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001523; retinoid metabolic process
GO:0006641; triglyceride metabolic process
GO:0007186; G-protein coupled receptor signaling pathway
GO:0010897; negative regulation of triglyceride catabolic process
GO:0010903; negative regulation of very-low-density lipoprotein particle remodeling
GO:0010916; negative regulation of very-low-density lipoprotein particle clearance
GO:0010987; negative regulation of high-density lipoprotein particle clearance
GO:0010989; negative regulation of low-density lipoprotein particle clearance
GO:0019433; triglyceride catabolic process
GO:0032489; regulation of Cdc42 protein signal transduction
GO:0033344; cholesterol efflux

And 15 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005769; early endosome
GO:0034361; very-low-density lipoprotein particle
GO:0034363; intermediate-density lipoprotein particle
GO:0034366; spherical high-density lipoprotein particle
GO:0042627; chylomicron
GO:0070062; extracellular exosome

Function:

GO:0005543; phospholipid binding
GO:0015485; cholesterol binding
GO:0030234; enzyme regulator activity
GO:0055102; lipase inhibitor activity
GO:0070653; high-density lipoprotein particle receptor binding

Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for APOC3

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Apoc3
Rattus norvegicus: Apoc3

In other databases

LongevityMap

This gene is present as APOC3