GenAge entry for EEF1E1 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 266)

HGNC symbol: EEF1E1
Aliases: AIMP3; P18
Common name: eukaryotic translation elongation factor 1 epsilon 1

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

The eukaryotic translation elongation factor 1 epsilon 1 (EEF1E1), also known as p18, is a well-known tumor suppressor, which plays a role in the ATM/ATR-mediated p53 (TP53) activation [2155].

Knockout mice result in early embryonic death (homozygous) or are born alive but show highly increased susceptibility to various cancers (heterozygous). On the other hand, transgenic mice overexpressing EEF1E1 constitutively have an imbalance in the protein levels of lamin A (LMNA) isoforms, and thus a significantly shorter mean lifespan and a phenotype characteristic to mouse progeroid models [2156].

The expression of p18 is downregulated in gastric and colorectal cancers [2157].

Cytogenetic information

Cytogenetic band: 6p24.3
Location: 8,073,360 bp to 8,102,595 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0006414; translational elongation
GO:0006418; tRNA aminoacylation for protein translation
GO:0006749; glutathione metabolic process
GO:0008285; negative regulation of cell proliferation
GO:0043065; positive regulation of apoptotic process
GO:0043517; positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:2000774; positive regulation of cellular senescence

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0070062; extracellular exosome

Function:

GO:0003746; translation elongation factor activity
GO:0004364; glutathione transferase activity
GO:0005515; protein binding

Show all GO terms

Protein interactions and network

No interactions in records.

Retrieve sequences for EEF1E1

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Eef1e1
Rattus norvegicus: Eef1e1

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Eef1e1

CellAge

This gene is present as EEF1E1

CellAge gene expression

This gene is present as EEF1E1