GenAge entry for GHRH (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 2)

HGNC symbol: GHRH
Aliases: GHRF
Common name: growth hormone releasing hormone

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: GHRH is secreted in the hypothalamus to stimulate the synthesis and secretion of growth hormone (GH1). Defects in the human GHRH gene cause dwarfism while hypersecretion causes gigantism, but it is unknown whether the ageing process is affected in these patients. Declines in GH1 with age may be due to a deficiency in GHRH [1354]. Knockout mice live 46% longer than controls: Females live 43% longer and males 51% longer, though maximum lifespan was only increased (by 33%) in females. Both males and females and markedly smaller than controls [3280]. Given these results, it is possible that GHRH is involved in some aspects of human ageing.

Cytogenetic information

Cytogenetic band: 20q11.2
Location: 37,251,086 bp to 37,256,896 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0007189; adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0019933; cAMP-mediated signaling
GO:0021984; adenohypophysis development
GO:0030252; growth hormone secretion
GO:0030819; positive regulation of cAMP biosynthetic process
GO:0032094; response to food
GO:0040018; positive regulation of multicellular organism growth
GO:0043568; positive regulation of insulin-like growth factor receptor signaling pathway
GO:0046005; positive regulation of circadian sleep/wake cycle, REM sleep

And 2 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005622; intracellular
GO:0043195; terminal bouton

Function:

GO:0016608; growth hormone-releasing hormone activity
GO:0031770; growth hormone-releasing hormone receptor binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: GHRHR
STRING interaction network

Retrieve sequences for GHRH

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ghrh
Mus musculus: Ghrh
Rattus norvegicus: Ghrh

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Ghrh