GenAge entry for GPX1 (Homo sapiens)

Gene name (HAGRID: 153)

HGNC symbol: GPX1
Aliases
Common name: glutathione peroxidase 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: Mostly present in erythrocytes, GPX1 protects from oxidative damage. Changes in GPX1 have been reported in mice during ageing and due to caloric restriction [243], but there is no direct evidence linking GPX1 to ageing. Mice without GPX1 are more susceptibility to oxidative stress, but do not show signs of premature ageing [741], except for cataracts [742]. Overexpression of GPX1 in mice results in insulin (INS) resistance and obesity [1066]. Results from transgenic mice overexpressing GPX1 in the heart suggest GPX1 could be beneficial to prevent cardiac failure [1711]. Its role, if any, in human ageing remains to be determined.

Cytogenetic information

Cytogenetic band: 3p21.3
Location: 49,357,176 bp to 49,358,358 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000302; response to reactive oxygen species
GO:0001659; temperature homeostasis
GO:0001885; endothelial cell development
GO:0002862; negative regulation of inflammatory response to antigenic stimulus
GO:0006195; purine nucleotide catabolic process
GO:0006641; triglyceride metabolic process
GO:0006749; glutathione metabolic process
GO:0007605; sensory perception of sound
GO:0008631; intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410; response to xenobiotic stimulus
GO:0009609; response to symbiotic bacterium

And 31 more GO terms

Cellular component:

GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0005759; mitochondrial matrix
GO:0005829; cytosol
GO:0070062; extracellular exosome
GO:0097413; Lewy body

Function:

GO:0004602; glutathione peroxidase activity
GO:0017124; SH3 domain binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TXN, ABL1
STRING interaction network

Retrieve sequences for GPX1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: gpx-4
Danio rerio: gpx1b
Mus musculus: Gpx1
Rattus norvegicus: Gpx1

In other databases

LongevityMap

This gene is present as GPX1