GenAge entry for IL2 (Homo sapiens)
Gene name (HAGRID: 46)
- HGNC symbol
- IL2
- Aliases
- IL-2; TCGF
- Common name
- interleukin 2
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
IL2 is a cytokine that has been associated with age-related changes at the immune system level [369]. Studies of polymorphisms in the human IL2 gene, however, have so far failed to find an association with human longevity [222].
Cytogenetic information
- Cytogenetic band
- 4q26-q27
- Location
- 122,451,471 bp to 122,456,495 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0000165; MAPK cascade
GO:0001933; negative regulation of protein phosphorylation
GO:0002250; adaptive immune response
GO:0002903; negative regulation of B cell apoptotic process
GO:0006955; immune response
GO:0007155; cell adhesion
GO:0007204; positive regulation of cytosolic calcium ion concentration
GO:0007205; protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007267; cell-cell signaling
GO:0008284; positive regulation of cell proliferation
GO:0030101; natural killer cell activation
And 23 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005622; intracellular
Show all GO termsFunction: GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005125; cytokine activity
GO:0005134; interleukin-2 receptor binding
GO:0008083; growth factor activity
GO:0019209; kinase activator activity
GO:0030246; carbohydrate binding
GO:0031851; kappa-type opioid receptor binding
GO:0043208; glycosphingolipid binding
Protein interactions and network
Retrieve sequences for IL2
Homologs in model organisms
In other databases
- LongevityMap
- This gene is present as IL2