GenAge entry for LEPR (Homo sapiens)
Gene name (HAGRID: 218)
- HGNC symbol
- LEPR
- Aliases
- OBR; CD295
- Common name
- leptin receptor
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
LEPR is the receptor for leptin (LEP) and is involved in LEP's signal transduction [1221]. The obese spontaneously hypertensive Koletsky rat has been associated with mutations in LEPR [217]. Deletion of LEPR in neurons of mice results in obesity [1742]. Polymorphisms in the human LEPR gene have been associated with obesity, body mass index, and fat mass [1745]. Like LEP, LEPR plays a role in fat metabolism and so could be involved in some aspects of age-related deterioration.
Cytogenetic information
- Cytogenetic band
- 1p31
- Location
- 65,420,652 bp to 65,637,493 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001525; angiogenesis
GO:0006112; energy reserve metabolic process
GO:0006909; phagocytosis
GO:0007166; cell surface receptor signaling pathway
GO:0007275; multicellular organism development
GO:0008203; cholesterol metabolic process
GO:0010507; negative regulation of autophagy
GO:0019953; sexual reproduction
GO:0030217; T cell differentiation
GO:0033210; leptin-mediated signaling pathway
GO:0042593; glucose homeostasis
And 9 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005886; plasma membrane
GO:0016021; integral component of membrane
GO:0016323; basolateral plasma membrane
GO:0043235; receptor complex
Show all GO termsFunction: GO:0004888; transmembrane signaling receptor activity
GO:0005515; protein binding
GO:0038021; leptin receptor activity
Protein interactions and network
Retrieve sequences for LEPR
Homologs in model organisms
No homologs found
In other databases
- LongevityMap
- This gene is present as LEPR