GenAge entry for LMNB1 (Homo sapiens)
Gene name (HAGRID: 181)
- HGNC symbol
- LMNB1
- Aliases
- Common name
- lamin B1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
- Description
LMNAB1 is, like LMNA, part of the nuclear lamina [1001]. LMNB1-null mice die shortly after birth [1724]. If the nuclear lamina is a player in human ageing, as some results from LMNA suggest [1307], then it is possible that LMNB1 also plays some role in human ageing.
Cytogenetic information
- Cytogenetic band
- 5q23.2
- Location
- 126,776,623 bp to 126,837,020 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: Cellular component: GO:0005635; nuclear envelope
GO:0005637; nuclear inner membrane
GO:0005638; lamin filament
GO:0005654; nucleoplasm
GO:0016020; membrane
GO:0016363; nuclear matrix
GO:0031965; nuclear membrane
Show all GO termsFunction: GO:0005198; structural molecule activity
GO:0005515; protein binding
GO:0043274; phospholipase binding
Protein interactions and network
- Protein-protein interacting partners in GenAge
- LMNA, EGF, RPA1, PRKCA, EMD, HSPA8, CDK1, CTNNB1, SPRTN
- STRING interaction network
