GenAge entry for PLAU (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 10)
- HGNC symbol
- PLAU
- Aliases
- URK; UPA
- Common name
- plasminogen activator, urokinase
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
PLAU is a protease that converts plasminogen to plasmin. It appears to affect murine ageing: its overexpression in the brain diminishes food consumption and extends longevity probably through a mechanism similar to caloric restriction [13]. It is unclear at present whether PLAU affects human ageing, despite some evidence linking PLAU to age-related neurological diseases [374].
Cytogenetic information
- Cytogenetic band
- 10q22.2
- Location
- 73,911,104 bp to 73,917,500 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0001666; response to hypoxia
GO:0006508; proteolysis
GO:0006935; chemotaxis
GO:0007165; signal transduction
GO:0007596; blood coagulation
GO:0010469; regulation of receptor activity
GO:0014909; smooth muscle cell migration
GO:0014910; regulation of smooth muscle cell migration
GO:0030335; positive regulation of cell migration
GO:0033628; regulation of cell adhesion mediated by integrin
GO:0042127; regulation of cell proliferation
And 4 more GO terms Cellular component: GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005886; plasma membrane
GO:0005925; focal adhesion
GO:0009986; cell surface
GO:0070062; extracellular exosome
Show all GO termsFunction: GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
Protein interactions and network
Retrieve sequences for PLAU
Homologs in model organisms
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Plau