GenAge entry for PLCG2 (Homo sapiens)

Gene name (HAGRID: 57)

HGNC symbol: PLCG2
Aliases
Common name: phospholipase C, gamma 2 (phosphatidylinositol-specific)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: PLCG2 catalyzes the hydrolysis of phospholipids and is crucial in intracellular signalling [398]. Clearly, PLCG2 is affected by ageing [952], though it is unclear whether PLCG2 influences human ageing.

Cytogenetic information

Cytogenetic band: 16q24.1
Location: 81,779,258 bp to 81,962,693 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0002092; positive regulation of receptor internalization
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0002316; follicular B cell differentiation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0009395; phospholipid catabolic process
GO:0010468; regulation of gene expression
GO:0016055; Wnt signaling pathway
GO:0019722; calcium-mediated signaling
GO:0030168; platelet activation
GO:0030183; B cell differentiation
GO:0032237; activation of store-operated calcium channel activity

And 11 more GO terms

Cellular component:

GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0070062; extracellular exosome

Function:

GO:0004435; phosphatidylinositol phospholipase C activity
GO:0004629; phospholipase C activity
GO:0004871; signal transducer activity
GO:0005515; protein binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, PTPN11, IRS1, EGFR, ERBB2, PRKCA, HSPD1, PIK3R1
STRING interaction network

Retrieve sequences for PLCG2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: plc-3
Danio rerio: plcg2
Drosophila melanogaster: sl
Mus musculus: Plcg2
Rattus norvegicus: Plcg2