GenAge entry for PLCG2 (Homo sapiens)

Gene name (HAGRID: 57)

HGNC symbol
PLCG2 
Aliases
 
Common name
phospholipase C, gamma 2 (phosphatidylinositol-specific) 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description

PLCG2 catalyzes the hydrolysis of phospholipids and is crucial in intracellular signalling [398]. Clearly, PLCG2 is affected by ageing [952], though it is unclear whether PLCG2 influences human ageing.

Cytogenetic information

Cytogenetic band
16q24.1
Location
81,779,258 bp to 81,962,693 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002092; positive regulation of receptor internalization
GO:0002223; stimulatory C-type lectin receptor signaling pathway
GO:0002316; follicular B cell differentiation
GO:0006661; phosphatidylinositol biosynthetic process
GO:0009395; phospholipid catabolic process
GO:0010468; regulation of gene expression
GO:0016055; Wnt signaling pathway
GO:0019722; calcium-mediated signaling
GO:0030168; platelet activation
GO:0030183; B cell differentiation
GO:0032237; activation of store-operated calcium channel activity
GO:0032481; positive regulation of type I interferon production
GO:0032496; response to lipopolysaccharide
GO:0032959; inositol trisphosphate biosynthetic process
GO:0038095; Fc-epsilon receptor signaling pathway
GO:0038096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043069; negative regulation of programmed cell death
GO:0043647; inositol phosphate metabolic process
GO:0050852; T cell receptor signaling pathway
GO:0050853; B cell receptor signaling pathway
GO:0051209; release of sequestered calcium ion into cytosol
Cellular component: GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0070062; extracellular exosome
Function: GO:0004435; phosphatidylinositol phospholipase C activity
GO:0004629; phospholipase C activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
SHC1, TP53, PTPN11, IRS1, EGFR, ERBB2, PRKCA, HSPD1, PIK3R1
STRING interaction network
Protein-Protein network diagram for PLCG2

Retrieve sequences for PLCG2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
plc-3
Danio rerio
plcg2
Drosophila melanogaster
sl
Mus musculus
Plcg2
Rattus norvegicus
Plcg2

Selected references

External links

EPD
ORF Accession
NM_002661
CDS Accession
NP_002652
OMIM
600220
HPRD
02570
Ensembl
PLCG2
UniProt/Swiss-Prot
PLCG2_HUMAN
GeneCards
PLCG2
Entrez Gene
5336
UniGene
413111
GenAtlas
PLCG2
Internet
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