GenAge entry for TPP2 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 273)

HGNC symbol: TPP2
Aliases
Common name: tripeptidyl peptidase II

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Description

In human embryonic kidney cells overexpression of TPP2 induces accelerated growth and resistance to apoptosis, correlated with the appearance of multiple chromosomal aberrations, numerical and structural centrosome abnormalities, and multipolar cell divisions, suggesting a role in the regulation of centrosome homeostasis and mitotic fidelity [2185].

Knockout in mice resulted in viable animals which are almost indistinguishable from their wild type littermates when young. After the age of 1 year mutant mice show an increased mortality and multiple signs of premature ageing. They exhibt an aged appearance, disheveled fur, large bald areas, reduced body mass, and loss of vigor. Mice also show symptoms characteristic of immunohematopoietic senescence, including accelerated thymic involution, lymphopenia, impaired proliferative T cell responses, extramedullary hematopoiesis, and inflammation. Premature cellular senescence in fibroblasts, coinciding with the upregulation of TP53 and the dysregulation of NFKB1 was also observed [2184].

Cytogenetic information

Cytogenetic band: 13q32-q33
Location: 102,596,936 bp to 102,679,173 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000209; protein polyubiquitination
GO:0006508; proteolysis

Cellular component:

GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol

Function:

GO:0004175; endopeptidase activity
GO:0004177; aminopeptidase activity
GO:0004252; serine-type endopeptidase activity
GO:0005515; protein binding
GO:0008240; tripeptidyl-peptidase activity
GO:0042277; peptide binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: POLB, SIRT7
STRING interaction network

Retrieve sequences for TPP2

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: F21H12.6
Danio rerio: tpp2
Drosophila melanogaster: TppII
Mus musculus: Tpp2
Rattus norvegicus: Tpp2
Schizosaccharomyces pombe: tpp2

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Tpp2