GenAge entry for ARNTL (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 251)

HGNC symbol: ARNTL
Aliases: MOP3; JAP3; BMAL1; PASD3; bHLHe5
Common name: aryl hydrocarbon receptor nuclear translocator-like

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description: ARNTL forms a heterodimer with CLOCK, which activates circadian rhythm-associated genes. Mice deficient in ARNTL have an impaired circadian behavior, reduced lifespan, and display symptoms of premature ageing associated in some tissues with increased levels of reactive oxygen species [1841]. BMAL1 deficient mice also have an increased activity of mTORC1, and treatment with rapamycin rescues their median lifespan by ~50% and maximum lifespan by ~25% [3627].

Cytogenetic information

Cytogenetic band: 11p15
Location: 13,277,727 bp to 13,387,265 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000060; protein import into nucleus, translocation
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0007283; spermatogenesis
GO:0007623; circadian rhythm
GO:0032007; negative regulation of TOR signaling
GO:0032922; circadian regulation of gene expression
GO:0042176; regulation of protein catabolic process
GO:0042634; regulation of hair cycle
GO:0042753; positive regulation of circadian rhythm
GO:0043161; proteasome-mediated ubiquitin-dependent protein catabolic process

And 16 more GO terms

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0016605; PML body
GO:0033391; chromatoid body
GO:0043231; intracellular membrane-bounded organelle

Function:

GO:0000976; transcription regulatory region sequence-specific DNA binding
GO:0000982; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001046; core promoter sequence-specific DNA binding
GO:0001047; core promoter binding
GO:0001190; transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0003677; DNA binding
GO:0005515; protein binding
GO:0017162; aryl hydrocarbon receptor binding
GO:0043425; bHLH transcription factor binding
GO:0043565; sequence-specific DNA binding
GO:0046982; protein heterodimerization activity

And 4 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: CREBBP, HIF1A, HSP90AA1, EP300, SIRT1, PPP1CA, CSNK1E, CLOCK
STRING interaction network

Retrieve sequences for ARNTL

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: arntl1b
Mus musculus: Arntl
Rattus norvegicus: Arntl

In other databases

GenAge model organism genes

A homolog of this gene for Mus musculus is present as Arntl

GenDR gene expression

A homolog of this gene for Mus musculus is present as Arntl

LongevityMap

This gene is present as ARNTL