GenAge entry for MT1E (Homo sapiens)
Gene name (HAGRID: 292)
- HGNC symbol
- MT1E
- Aliases
- MTD; MT1
- Common name
- metallothionein 1E
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
- Description
MT1E seems to play a role protecting against oxidative stress, although its exact functions are unknown. Cardiac-specific overexpression of MT1E in mice increased lifespan by 14% while attenuating oxidative stress in the heart [3251]. Further studies are warranted.
Cytogenetic information
- Cytogenetic band
- 16q13
- Location
- 56,625,673 bp to 56,627,113 bp
- Orientation
- Plus strand
Protein information
- Gene Ontology
-
Process: GO:0045926; negative regulation of growth
GO:0071276; cellular response to cadmium ion
GO:0071294; cellular response to zinc ion
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0048471; perinuclear region of cytoplasm
Show all GO termsFunction: GO:0008270; zinc ion binding
Protein interactions and network
No interactions in records.
Retrieve sequences for MT1E
Homologs in model organisms
No homologs found
In other databases
- CellAge gene expression
- This gene is present as MT1E